Two new cytotoxic labdane diterpenes from the rhizomes of Hedychium coronarium

  • Bioorg Med Chem Lett. 2010 Dec 15;20(24):7544-8. doi: 10.1016/j.bmcl.2010.09.024.
G Suresh  1 ,  P Prabhakar Reddy ,  K Suresh Babu ,  Thokhir Basha Shaik ,  Shasi Vardhan Kalivendi
Affiliations
  • 1. Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Hyderabad, India.
PMID: 21106458 DOI: 10.1016/j.bmcl.2010.09.024
Abstract

The phytochemical investigation of the hexane extract of the Hedychium coronarium led to the isolation and identification of two new labdane diterpenes (1 and 2) along with 10 known metabolites (3-12). The structures of the new compounds were established on the basis of spectroscopic data analysis (1D and 2D NMR and MS). Cytotoxic activities of the isolates were studied against the A-549 (lung Cancer), SK-N-SH (human neuroblastoma), MCF-7 (breast Cancer) and HeLa (cervical Cancer) cell lines.