1. Epigenetics PI3K/Akt/mTOR Autophagy
  2. AMPK Autophagy
  3. Malvidin-3-O-arabinoside chloride

Malvidin-3-O-arabinoside chloride 

Cat. No.: HY-N9349
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Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy.

For research use only. We do not sell to patients.

Malvidin-3-O-arabinoside chloride Chemical Structure

Malvidin-3-O-arabinoside chloride Chemical Structure

CAS No. : 28500-04-1

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Description

Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy[1].

In Vitro

Malvidin-3-O-arabinoside chloride (M3A chloride, 50-400 μM) pretreatment remarkably upregulates LAMP-1 expression, which indicates elevated lysosomal mass. M3A also successfully restores lysosomal acidity and subsequently strengthenes lysosomal functions. M3A stimulates phosphorylation of AMP-activated protein kinase (AMPK), a master regulator of autophagy[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Autophagy Assay[1]

Cell Line: Caco-2 cell line.
Concentration: 50, 100, 200 and 400 μM.
Incubation Time: 24 h (then treated with or without 10 μM chloroquine (CQ) for another 1 h).
Result: Notably inhibited excess ROS generation.
200 μM and 400 μM M3A pretreatment significantly enhanced 14% and 16% of GSH level.
Enhanced autophagy flux.
Significantly up-regulate the LC3-II/LC3-I ratio.
Molecular Weight

498.86

Formula

C22H23ClO11

CAS No.
SMILES

COC1=CC(C2=[O+]C3=CC(O)=CC(O)=C3C=C2O[C@H]4[C@H](O)[C@@H](O)[C@@H](O)CO4)=CC(OC)=C1O.[Cl-]

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Malvidin-3-O-arabinoside chloride
Cat. No.:
HY-N9349
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