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Cat. No.: HY-168044

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ALKBH1-IN-3

ALKBH1-IN-3 is a potent DNA N6-methyladenine (6mA) demethylase ALKBH1 inhibitor. ALKBH1-IN-3 increases the abundance of 6mA, inhibits cell viability and upregulates the AMP-activated protein kinase (AMPK) signaling pathway in gastric cancer cell lines HGC27 and AGS. ALKBH1-IN-3 is promising for research of cancers, including gastric cancer.

For research use only. We do not sell to patients.

Formula: C₁₆H₁₄N₄O₄
Molecular Weight:326.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

ALKBH1-IN-3 Chemical Structure

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Top Publications Citing

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All AMPK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
AGS	IC₅₀	155.3 μM Compound: 29	Anti-viability effect in human AGS cells incubated for 96 hrs by MTT assay Anti-viability effect in human AGS cells incubated for 96 hrs by MTT assay	[PMID: 39225755]
HGC-27	IC₅₀	>200 μM Compound: 29	Anti-viability effect in human HGC-27 cells incubated for 96 hrs by MTT assay Anti-viability effect in human HGC-27 cells incubated for 96 hrs by MTT assay	[PMID: 39225755]

Chemical Information

Molecular Weight 326.31
Formula C₁₆H₁₄N₄O₄
SMILES

OC(C1=CN(N=C1)C2=NC=C(C=N2)OCC3=CC(OC)=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li F, et al. Structural Optimization and Structure-Activity Relationship of 1H-Pyrazole-4-carboxylic Acid Derivatives as DNA 6mA Demethylase ALKBH1 Inhibitors and Their Antigastric Cancer Activity. J Med Chem. 2024 Sep 12;67(17):15456-15475. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
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ALKBH1-IN-3

All AMPK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ALKBH1-IN-3 Related Classifications

HY-168044 Related Classifications