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Metformin (glycinate)

(Synonyms: 1,1-Dimethylbiguanide (glycinate))
136 Cited Publications
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Based on 136 publication(s) in Google Scholar

Metformin (1,1-Dimethylbiguanide) glycinate inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin glycinate exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin glycinate also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin glycinate regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo.

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  • CAS No.: 121369-64-0
  • Formula: C6H16N6O2
  • Molecular Weight:204.23
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Metformin (glycinate) Chemical Structure
    Metformin (glycinate) Chemical Structure
  • Experimental Validation Results for Metformin (glycinate)
  • Experimental Validation Results for Metformin (glycinate)
  • Experimental Validation Results for Metformin (glycinate)
  • Experimental Validation Results for Metformin (glycinate)
  • Experimental Validation Results for Metformin (glycinate)
CAS No.: 121369-64-0
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WBRT-PCR
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  • Metformin (glycinate) Chemical Structure
    Metformin (glycinate) Chemical Structure
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    Metformin (glycinate) purchased from MedChemExpress. Usage Cited in: Nature. 2025 Feb;638(8052):1112-1121. [Abstract]

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     Metformin (2 mM; 16 h) significantly inhibits the mRNA expression of FOXM1 downstream genes (CDC25B, CCNA2) in HEK293T cells.

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    Metformin (glycinate) purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Mar 10:S2090-1232(25)00174-2. [Abstract]

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     STAT3 levels in hBMSCs treated with metformin and the miR-140-3p inhibitor.

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    Metformin (glycinate) purchased from MedChemExpress. Usage Cited in: Cell Res. 2023 Dec;33(12):904-922. [Abstract]

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     Cells were treated with mannose, MK-8722 (1 μM) or Metformin (1 mM) for 6 h. GSDME was immunoprecipitated using anti-GSDME antibody, and then the phosphorylation levels of GSDME T6 were detected.

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    Metformin (glycinate) purchased from MedChemExpress. Usage Cited in: Circulation. 2023 Jan 10;147(2):158-174. [Abstract]

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     Metformin. Western blot analysis of CB2R in the heart from db/db diabetic (DM) mice at different ages.

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    Metformin (glycinate) purchased from MedChemExpress. Usage Cited in: Front Immunol. 2016 Dec 12:7:597. [Abstract]

    Customer Validation
     Metformin increases adenosine triphosphate-induced inflammasome activation in bone marrow-derived macrophages. (A) Cells are treated. Indicated protein levels in both cell lysates and supernatants are evaluated by western blotting. β-Tubulin is used as a loading control for cell lysates. (B–D) The quantitative analyses of the active caspase-1p10 (B), mature interleukin-1β (C), and HMGB1 (D) levels in the supernatants (A) are shown.

  • Metformin (glycinate)