Multi-kinase-IN-12
Multi-kinase-IN-12 is a non-selective multi-target inhibitor, with IC50 values against human targets as follows: Flt3 < 0.001 μM, c-Src 0.002 μM, KDR 0.004 μM, Eph-A2, MNK-1 and Flt1 0.011 μM, Lck 0.016 μM, Rsk1 0.21 μM, and α2 subunit of AMPK 0.041 μM. Multi-kinase-IN-12 can be used in research related to solid tumors.
For research use only. We do not sell to patients.
- CAS No.: 597544-21-3
- Formula: C23H23N5O2
- Molecular Weight:401.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Multi-kinase-IN-12 potently inhibits the recombinant human AMPK α2/β1/γ1 heterotrimer with an IC50 of 0.04 μM[1].
Multi-kinase-IN-12 (1-10 μM; 6 h) inhibits cellular AMPK activity in MEF cells (detected via the phosphorylation level of ACC), with significant inhibition observed following treatment with 10 μM for 6 hours[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mouse embryonic fibroblast (MEF) cells
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Concentration:1, 5 and 10 μM
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Incubation Time:6 h
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Result:Reduced ACC phosphorylation to ~1.2-fold of untreated control at 1 μM.
Reduced ACC phosphorylation to ~1.1-fold of untreated control at 5 μM.
Significantly reduced ACC phosphorylation to ~0.5-fold of untreated control at 10 μM.
Chemical Information
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CAS No. 597544-21-3
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Molecular Weight 401.47
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Formula C23H23N5O2
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SMILES
N=1C=CC(=CC1)C=2C=NN3C=C(C=NC23)C=4C=CC(OCCN5CCOCC5)=CC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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