Multi-kinase-IN-12
Multi-kinase-IN-12 is a non-selective multi-target inhibitor, with IC50 values against human targets as follows: Flt3 < 0.001 μM, c-Src 0.002 μM, KDR 0.004 μM, Eph-A2, MNK-1 and Flt1 0.011 μM, Lck 0.016 μM, Rsk1 0.21 μM, and α2 subunit of AMPK 0.041 μM. Multi-kinase-IN-12 can be used in research related to solid tumors.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 597544-21-3
- Formel: C23H23N5O2
- Molecular Weight:401.47
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
In Vitro
Multi-kinase-IN-12 potently inhibits the recombinant human AMPK α2/β1/γ1 heterotrimer with an IC50 of 0.04 μM[1].
Multi-kinase-IN-12 (1-10 μM; 6 h) inhibits cellular AMPK activity in MEF cells (detected via the phosphorylation level of ACC), with significant inhibition observed following treatment with 10 μM for 6 hours[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:Mouse embryonic fibroblast (MEF) cells
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Concentration:1, 5 and 10 μM
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Incubation Time:6 h
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Result:Reduced ACC phosphorylation to ~1.2-fold of untreated control at 1 μM.
Reduced ACC phosphorylation to ~1.1-fold of untreated control at 5 μM.
Significantly reduced ACC phosphorylation to ~0.5-fold of untreated control at 10 μM.
Chemical Information
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CAS. Nr. 597544-21-3
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Molecular Weight 401.47
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Formel C23H23N5O2
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SMILES
N=1C=CC(=CC1)C=2C=NN3C=C(C=NC23)C=4C=CC(OCCN5CCOCC5)=CC4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Multi-kinase-IN-12 Related Classifications
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