2. Epigenetics PI3K/Akt/mTOR Protein Tyrosine Kinase/RTK MAPK/ERK Pathway
  3. AMPK FLT3 Src VEGFR Ephrin Receptor MNK Ribosomal S6 Kinase (RSK)
  4. Multi-kinase-IN-12

Multi-kinase-IN-12 is a non-selective multi-target inhibitor, with IC50 values against human targets as follows: Flt3 < 0.001 μM, c-Src 0.002 μM, KDR 0.004 μM, Eph-A2, MNK-1 and Flt1 0.011 μM, Lck 0.016 μM, Rsk1 0.21 μM, and α2 subunit of AMPK 0.041 μM. Multi-kinase-IN-12 can be used in research related to solid tumors.

For research use only. We do not sell to patients.

Multi-kinase-IN-12

Multi-kinase-IN-12 Chemical Structure

CAS No. : 597544-21-3

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Multi-kinase-IN-12 Related Antibodies

Top Publications Citing Use of Products

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

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Lck Fyn Blk Fgr Hck Lyn Yes SRC-3

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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EphB EphA

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MNK1 MNK2 MNK

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p70S6K RSK2 RSK3 RSK4

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Description

Multi-kinase-IN-12 is a non-selective multi-target inhibitor, with IC50 values against human targets as follows: Flt3 < 0.001 μM, c-Src 0.002 μM, KDR 0.004 μM, Eph-A2, MNK-1 and Flt1 0.011 μM, Lck 0.016 μM, Rsk1 0.21 μM, and α2 subunit of AMPK 0.041 μM. Multi-kinase-IN-12 can be used in research related to solid tumors[1].

In Vitro

Multi-kinase-IN-12 potently inhibits the recombinant human AMPK α2/β1/γ1 heterotrimer with an IC50 of 0.04 μM[1].
Multi-kinase-IN-12 (1-10 μM; 6 h) inhibits cellular AMPK activity in MEF cells (detected via the phosphorylation level of ACC), with significant inhibition observed following treatment with 10 μM for 6 hours[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Multi-kinase-IN-12 Related Antibodies

Western Blot Analysis[1]

Cell Line: Mouse embryonic fibroblast (MEF) cells
Concentration: 1, 5 and 10 μM
Incubation Time: 6 h
Result: Reduced ACC phosphorylation to ~1.2-fold of untreated control at 1 μM.
Reduced ACC phosphorylation to ~1.1-fold of untreated control at 5 μM.
Significantly reduced ACC phosphorylation to ~0.5-fold of untreated control at 10 μM.
Molecular Weight

401.47

Formula

C23H23N5O2
CAS No.
SMILES

N=1C=CC(=CC1)C=2C=NN3C=C(C=NC23)C=4C=CC(OCCN5CCOCC5)=CC4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Multi-kinase-IN-12 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multi-kinase-IN-12597544-21-3AMPKFLT3SrcVEGFREphrin ReceptorMNKRibosomal S6 Kinase (RSK)AMP-activated protein kinaseCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Vascular endothelial growth factor receptorMitogen activated protein kinase interacting kinaseMAP kinase interacting kinaseMAPK interacting kinaseS6KFlt3AMPK α2 subunitKDRLckc-SrcEph-A2Rsk1acetyl CoA carboxylase 1MNK-1Flt1Inhibitorinhibitorinhibit

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