1. Metabolic Enzyme/Protease
  2. Microsomal Triglyceride Transfer Protein (MTP)
  3. Lomitapide mesylate

Lomitapide mesylate  (Synonyms: AEGR-733 mesylate; BMS-201038 mesylate)

Cat. No.: HY-14668
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Lomitapide mesylate(AEGR-733; BMS-201038) is an inhibitor of microsomal triglyceride-transfer protein (MTP) wtih in vitro IC50 of 8 nM.

For research use only. We do not sell to patients.

Lomitapide mesylate Chemical Structure

Lomitapide mesylate Chemical Structure

CAS No. : 202914-84-9

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Description

Lomitapide mesylate(AEGR-733; BMS-201038) is an inhibitor of microsomal triglyceride-transfer protein (MTP) wtih in vitro IC50 of 8 nM. IC50 value: 8 nM [1] Target: MTP inhibitor Lomitapide is a small-molecule, microsomal triglyceride transfer protein (MTP) inhibitor, for the treatment of both familial and primary hypercholesterolemia. Oral, once-daily lomitapide will be targeted at patients resistant to HMG-CoA reductase inhibitors (statins) either due to abnormalities in liver function or to discontinuation because of muscle pain.

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Molecular Weight

789.83

Formula

C40H41F6N3O5S

CAS No.
SMILES

O=C(C1(CCCCN2CCC(NC(C3=CC=CC=C3C4=CC=C(C(F)(F)F)C=C4)=O)CC2)C5=C(C6=C1C=CC=C6)C=CC=C5)NCC(F)(F)F.O=S(C)(O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Lomitapide mesylate
Cat. No.:
HY-14668
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