2. Others PI3K/Akt/mTOR Epigenetics NF-κB
  3. Drug Derivative AMPK IKK NF-κB
  4. Nandinine

Nandinine is an orally active derivative of Berberine (HY-N0716). Nandinine enhances AMPK activity, inhibits the activation of IKKβ/NF-κB, and regulates the phosphorylation of IRS-1. Nandinine reverses the abnormal production of adipokines, promotes insulin-mediated glucose uptake, and alleviates insulin resistance. Nandinine improves glucose tolerance and increases the insulin sensitivity index in mice. Nandinine can be used in studies related to insulin resistance.

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Nandinine

Nandinine Chemical Structure

CAS No. : 572-76-9

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Nandinine Related Antibodies

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Description

Nandinine is an orally active derivative of Berberine (HY-N0716). Nandinine enhances AMPK activity, inhibits the activation of IKKβ/NF-κB, and regulates the phosphorylation of IRS-1. Nandinine reverses the abnormal production of adipokines, promotes insulin-mediated glucose uptake, and alleviates insulin resistance. Nandinine improves glucose tolerance and increases the insulin sensitivity index in mice. Nandinine can be used in studies related to insulin resistance[1].

IC50 & Target[1]

IKKβ

 

In Vitro

Nandinine (10 µM; 1 h) significantly reverses the dysregulated adipokine secretion in differentiated 3T3-L1 adipocytes induced by Mac-CM by reducing the levels of pro-inflammatory TNF-α and IL-6 and restoring the level of anti-inflammatory adiponectin[1].
Nandinine (10 µM; 1 h) significantly inhibits the activation of the IKKβ/NF-κB pathway in post-differentiation 3T3-L1 adipocytes induced by Mac-CM[1].
Nandinine (10 µM; pretreated for 1 hour and co-incubated with Mac-CM for 30 minutes) significantly restores insulin-mediated signal transduction and glucose uptake in Mac-CM-treated differentiated 3T3-L1 adipocytes by regulating IRS-1 phosphorylation and the activity of the downstream PI3K/Akt/GLUT-4 pathway[1].
Nandinine (10 µM; 1 h) significantly activates AMPK in differentiated 3T3-L1 adipocytes under normal conditions and those treated with Mac-CM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nandinine Related Antibodies

Western Blot Analysis[1]

Cell Line: differentiated 3T3-L1 adipocytes
Concentration: 10 µM
Incubation Time: 1 h pretreatment; 30 min stimulation with Mac-CM
Result: Reversed Mac-CM-induced increases in IKKβ phosphorylation.
Reversed Mac-CM-induced increases in IκBα phosphorylation.
Reversed Mac-CM-induced increases in p65 phosphorylation.
Reversed Mac-CM-induced increases in nuclear p65 expression.
Reduced the Mac-CM-enhanced interaction between IκBα and IKKβ.
All changes were statistically significant at P < 0.01 compared to Mac-CM-only treatment.
In Vivo

Nandinine (100-200 mg/kg; p.o.; single dose) effectively ameliorates Mac-CM-induced glucose intolerance and reduces insulin resistance in male ICR mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (male, 6-8 weeks of age)[1]
Dosage: 100 mg/kg; 200 mg/kg
Administration: p.o.; single dose
Result: Restored glucose disposal compared to Mac-CM-only treated mice.
Reduced the area under the curve for glucose (AUC-G) compared to Mac-CM-only treated mice.
Decreased the homeostasis model assessment of insulin resistance (HOMA-IR) index compared to Mac-CM-only treated mice.
Molecular Weight

325.36

Formula

C19H19NO4
CAS No.
SMILES

OC1=C2CN3[C@](CC2=CC=C1OC)([H])C4=CC(OCO5)=C5C=C4CC3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Nandinine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nandinine572-76-9Drug DerivativeAMPKIKKNF-κBDrug derivativeAMP-activated protein kinaseIκB kinaseI kappa B kinase Nuclear factor-κBNuclear factor-kappaBadipocytesICR micePI3K/Akt pathwayTNF-α3T3-L1 adipocytesIL-6IKKβIRS-1adiponectinInhibitorinhibitorinhibit

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