Lipid-lowering agent-2
Lipid-lowering agent-2 (Compound 14d) is an orally active lipid-lowering agent with an EC50 of 0.06 μM. Lipid-lowering agent-2 inhibits the lipid synthesis, activates the AMPK signaling pathway, and exhibits anti-obesity effect. Lipid-lowering agent-2 inhibits food intake, improves the glucose metabolism, and reduces the body weight and adipose tissue in high-fat diet (HFD)-induced obese mice.
For research use only. We do not sell to patients.
- Formula: C25H27N7O
- Molecular Weight:441.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All AMPK Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 3T3-L1 | CC50 |
34.3 μM
Compound: 14d
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Cytotoxicity against confluent mouse 3T3-L1 preadipocytes assessed as reduction in cell viability measured after 24 hrs by SRB method
Cytotoxicity against confluent mouse 3T3-L1 preadipocytes assessed as reduction in cell viability measured after 24 hrs by SRB method
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[PMID: 38996004] |
| 3T3-L1 | EC50 |
0.06 μM
Compound: 14d
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Lipid lowering activity in confluent mouse 3T3-L1 preadipocytes assessed as reduction in triglyceride level incubated for 9 days by oil red o staining based analysis
Lipid lowering activity in confluent mouse 3T3-L1 preadipocytes assessed as reduction in triglyceride level incubated for 9 days by oil red o staining based analysis
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[PMID: 38996004] |
Chemical Information
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Molecular Weight 441.53
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Formula C25H27N7O
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SMILES
O=C(N/N=C/C1=C(NC2=CC=CC=C21)C3=NC4=C(C(NCCN5CCCC5)=N3)C=CC=C4)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)