Magnesium acetate tetrahydrate, for molecular biology 

Magnesium acetate tetrahydrate, for molecular biology is a carboxylic acid and short-chain fatty acid (SCFAs). Magnesium acetate tetrahydrate, for molecular biology activates AMPK, increases ROS, cleaved caspase 9, PPARα, downregulates SREBP-1c, ChREBP expression. Magnesium acetate tetrahydrate, for molecular biology exhibits antifungal activity against Saccharomyces cerevisiae W303-1A. Magnesium acetate tetrahydrate, for molecular biology regulates energy metabolism. Magnesium acetate tetrahydrate, for molecular biology has anticancer activity against gastric cancer. Magnesium acetate tetrahydrate, for molecular biology induces writhing reaction and ulcerative colitis. Magnesium acetate tetrahydrate, for molecular biology can be used in the researches for gastric cancer, ulcerative colitis, hepatic steatosis, and pain^{[1][2][3][4][5][6][7][8][9]}.

Magnesium acetate tetrahydrate (Acetic acid; 2-5 μM; 24 h) induces cancer cell-selective death in gastric cancer cells (RGK1) via oxidative stress, while having minor effects on normal gastric mucosal cells (RGM1)^[3].
Magnesium acetate tetrahydrate (Acetic acid; 20-200 mM; 200 min) induces programmed cell death in Saccharomyces cerevisiae W303-1A^[4].
Magnesium acetate tetrahydrate (Acetic acid; 5 mM; 15 d) suppresses the increase in disaccharidase activity (sucrase, maltase, trehalase, lactase) in Caco-2 cells without affecting cell growth or glucose transport^[5].
Magnesium acetate tetrahydrate (Acetic acid; 8-7.2 mM; 3 h) activates the AMPKα signaling pathway by consuming ATP to increase the AMP/ATP ratio in bovine hepatocytes, upregulating lipid oxidation genes, downregulating lipogenic genes, and reducing intracellular triglyceride content^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Magnesium acetate tetrahydrate (Acetic acid; 0.56%; i.p.) significantly induces writhing responses in C57BL/6J mice^[7].
Magnesium acetate tetrahydrate Acetic acid (Acetic acid; 5% v/v; rectal instillation) induces ulcerative colitis in mice, causing weight loss, diarrhea, colonic inflammation, and tissue damage^[8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

214.45

C₄H₁₄MgO₈

16674-78-5

[Mg(CH3CO2)2.4H2O]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Barbier Jr J, et al. Total oxidation of acetic acid in aqueous solutions over noble metal catalysts. Journal of Catalysis, 1998, 177(2): 378-385.

  [2]. Terasaki M, et al. Acetic acid is an oxidative stressor in gastric cancer cells. J Clin Biochem Nutr. 2018 Jul;63(1):36-41.  [Content Brief]

  [3]. Ludovico P, et al. Saccharomyces cerevisiae commits to a programmed cell death process in response to acetic acid. Microbiology (Reading). 2001 Sep;147(Pt 9):2409-2415.  [Content Brief]

  [4]. Ogawa N, et al. Acetic acid suppresses the increase in disaccharidase activity that occurs during culture of caco-2 cells. J Nutr. 2000 Mar;130(3):507-13.  [Content Brief]

  [5]. Li X, et al. Acetic acid activates the AMP-activated protein kinase signaling pathway to regulate lipid metabolism in bovine hepatocytes. PLoS One. 2013 Jul 4;8(7):e67880.  [Content Brief]

  [6]. Stevenson GW, et al. Targeting pain-suppressed behaviors in preclinical assays of pain and analgesia: effects of morphine on acetic acid-suppressed feeding in C57BL/6J mice. J Pain. 2006 Jun;7(6):408-16.  [Content Brief]

  [7]. Niu X, et al. Protective effect of sanguinarine against acetic acid-induced ulcerative colitis in mice. Toxicol Appl Pharmacol. 2013 Mar 15;267(3):256-65.  [Content Brief]

  [8]. Granado-Serrano AB, et al. Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia. Sci Rep. 2019 Feb 11;9(1):1772.  [Content Brief]