硫酸マグネシウム
Based on 1 Customer Validation
Magnesium sulfate is a calcium antagonist and a potent L-type calcium channel inhibitor, as well as a tocolytic. Magnesium sulfate has anti-inflammatory, anticonvulsant, vasodilatory, and neuroprotective effects. Magnesium sulfate can be used in the research of diseases such as preeclampsia/eclampsia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.03%
- CAS 番号: 7487-88-9
- 分子式: MgSO4
- 分子量:120.37
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-Y0332B
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HY-N3025
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HY-W019883
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HY-Y1369C
Manganese sulfate monohydrate, for cell cultureInorganic Manganese Salt Toxicant -
HY-Y0537
Potassium chloride, AR, 99.5%Potassium Supplement -
HY-108536D
Calcium chloride dihydrate, for cell culture, 99%Biochemical Reagent -
HY-Y0406H
Calcium chloride anhydrous, powder, 97%Biochemical Assay Reagents -
HY-Y0320
Dimethyl sulfoxide, meets analytical specification of Ch.P.Aprotic Solvent -
HY-D0861
EGTACalcium Ion Chelator -
HY-Y1878
Copper(Ⅱ) sulfateBiochemical Reagent -
HY-W019981B
Magnesium chloride hexahydrate, for molecular biologySource of Magnesium Ion -
HY-Y1267D
Magnesium sulfate, for cell cultureAnti-Inflammatory Agent
生物活性
製品説明
体外実験
Magnesium sulfate (3 mM) inhibits phosphatidylinositol-4,5-bisphosphate-specific phospholipase C activity and subsequent calcium release in cultured myometrial cells[2].
Magnesium sulfate (20 mM; 6 h) inhibits the LPS (HY-D1056)-induced inflammatory molecules production and NF-κB activation in RAW264.7 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 cells treated with 100 ng/mL of LPS (HY-D1056)
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Concentration:20 mM
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Incubation Time:6 h
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Result:Inhibtied the levels of iNOS and COX-2.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD-1 out-bred timed pregnant mice, and intrauterine inflammation was induced by intrauterine injection of LPS (HY-D1056) on embryonic day 15[4]
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Dosage:270 mg/kg, followed by 27 mg/kg every 20 minutes for 4 hours, and then an additional 270 mg/kg
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Administration:Intraperitoneal injection
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Result:Prevented LPS-induced neuronal injury in fetal mouse brains, as evidenced by maintaining normal neuronal morphology, including dendritic processes and MAP2 staining, without significantly affecting the expression of proinflammatory cytokines or cell death markers.
化学情報
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CAS 番号 7487-88-9
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性状 Solid
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分子量 120.37
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分子式 MgSO4
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Color White to off-white
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SMILES
[Mg]=S(O[O])([O])=O
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別名
Magnesium sulfate
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外:
H2O : 25 mg/mL (207.69 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (291 KB)
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SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Ramsey PS, et al. Magnesium sulfate as a tocolytic agent. Semin Perinatol. 2001;25(4):236-247. [Content Brief]
[2]. Hurd WW, et al. Magnesium sulfate inhibits the oxytocin-induced production of inositol 1,4,5-trisphosphate in cultured human myometrial cells. Am J Obstet Gynecol. 2002 Aug;187(2):419-24. [Content Brief]
[3]. Lin CY, et al. L-type calcium channels are involved in mediating the anti-inflammatory effects of magnesium sulphate. Br J Anaesth. 2010 Jan;104(1):44-51. [Content Brief]
[4]. Burd I, et al. Magnesium sulfate reduces inflammation-associated brain injury in fetal mice. Am J Obstet Gynecol. 2010 Mar;202(3):292.e1-9. [Content Brief]
[5]. Okusanya BO, et al. Clinical pharmacokinetic properties of magnesium sulphate in women with pre-eclampsia and eclampsia. BJOG. 2016;123(3):356-366. [Content Brief]
[6]. Hunter LA, et al. Magnesium sulfate: past, present, and future. J Midwifery Womens Health. 2011 Nov-Dec;56(6):566-74. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 8.3077 mL | 41.5386 mL | 83.0772 mL | 207.6929 mL |
| 5 mM | 1.6615 mL | 8.3077 mL | 16.6154 mL | 41.5386 mL | |
| 10 mM | 0.8308 mL | 4.1539 mL | 8.3077 mL | 20.7693 mL | |
| 15 mM | 0.5538 mL | 2.7692 mL | 5.5385 mL | 13.8462 mL | |
| 20 mM | 0.4154 mL | 2.0769 mL | 4.1539 mL | 10.3846 mL | |
| 25 mM | 0.3323 mL | 1.6615 mL | 3.3231 mL | 8.3077 mL | |
| 30 mM | 0.2769 mL | 1.3846 mL | 2.7692 mL | 6.9231 mL | |
| 40 mM | 0.2077 mL | 1.0385 mL | 2.0769 mL | 5.1923 mL | |
| 50 mM | 0.1662 mL | 0.8308 mL | 1.6615 mL | 4.1539 mL | |
| 60 mM | 0.1385 mL | 0.6923 mL | 1.3846 mL | 3.4615 mL | |
| 80 mM | 0.1038 mL | 0.5192 mL | 1.0385 mL | 2.5962 mL | |
| 100 mM | 0.0831 mL | 0.4154 mL | 0.8308 mL | 2.0769 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Magnesium sulfate 関連分類
HY-Y1267 関連分類
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