Magnesium sulfate
Based on 1 Customer Validation
Magnesium sulfate is a calcium antagonist and a potent L-type calcium channel inhibitor, as well as a tocolytic. Magnesium sulfate has anti-inflammatory, anticonvulsant, vasodilatory, and neuroprotective effects. Magnesium sulfate can be used in the research of diseases such as preeclampsia/eclampsia.
For research use only. We do not sell to patients.
- Purity: 99.03%
- CAS No.: 7487-88-9
- Formula: MgSO4
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Magnesium sulfate (3 mM) inhibits phosphatidylinositol-4,5-bisphosphate-specific phospholipase C activity and subsequent calcium release in cultured myometrial cells[2].
Magnesium sulfate (20 mM; 6 h) inhibits the LPS (HY-D1056)-induced inflammatory molecules production and NF-κB activation in RAW264.7 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 cells treated with 100 ng/mL of LPS (HY-D1056)
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Concentration:20 mM
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Incubation Time:6 h
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Result:Inhibtied the levels of iNOS and COX-2.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD-1 out-bred timed pregnant mice, and intrauterine inflammation was induced by intrauterine injection of LPS (HY-D1056) on embryonic day 15[4]
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Dosage:270 mg/kg, followed by 27 mg/kg every 20 minutes for 4 hours, and then an additional 270 mg/kg
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Administration:Intraperitoneal injection
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Result:Prevented LPS-induced neuronal injury in fetal mouse brains, as evidenced by maintaining normal neuronal morphology, including dendritic processes and MAP2 staining, without significantly affecting the expression of proinflammatory cytokines or cell death markers.
Chemical Information
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CAS No. 7487-88-9
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Appearance Solid
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Formula MgSO4
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Color White to off-white
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SMILES
[Mg]=S(O[O])([O])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 25 mg/mL (Need ultrasonic)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
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Handling Instructions (2659 KB)
References
[1]. Ramsey PS, et al. Magnesium sulfate as a tocolytic agent. Semin Perinatol. 2001;25(4):236-247. [Content Brief]
[2]. Hurd WW, et al. Magnesium sulfate inhibits the oxytocin-induced production of inositol 1,4,5-trisphosphate in cultured human myometrial cells. Am J Obstet Gynecol. 2002 Aug;187(2):419-24. [Content Brief]
[3]. Lin CY, et al. L-type calcium channels are involved in mediating the anti-inflammatory effects of magnesium sulphate. Br J Anaesth. 2010 Jan;104(1):44-51. [Content Brief]
[4]. Burd I, et al. Magnesium sulfate reduces inflammation-associated brain injury in fetal mice. Am J Obstet Gynecol. 2010 Mar;202(3):292.e1-9. [Content Brief]
[5]. Okusanya BO, et al. Clinical pharmacokinetic properties of magnesium sulphate in women with pre-eclampsia and eclampsia. BJOG. 2016;123(3):356-366. [Content Brief]
[6]. Hunter LA, et al. Magnesium sulfate: past, present, and future. J Midwifery Womens Health. 2011 Nov-Dec;56(6):566-74. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Magnesium sulfate Related Classifications
HY-Y1267 Related Classifications
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