Magnesium sulfate, for cell culture
Based on 1 Customer Validation
Magnesium sulfate, for cell culture is a bioreagent. Magnesium sulfate is a calcium antagonist and a potent L-type calcium channel inhibitor, as well as a tocolytic. Magnesium sulfate has anti-inflammatory, anticonvulsant, vasodilatory, and neuroprotective effects. Magnesium sulfate can be used in the research of diseases such as preeclampsia/eclampsia.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 7487-88-9
- Formula: MgSO4
- Molecular Weight:120.37
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-Y0406E
Calcium chloride anhydrous, for cell culture
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HY-B0389
D-Glucose
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HY-Y1267
Magnesium sulfate
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HY-Y0332B
Potassium dihydrogen phosphate, AR,99.5%
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HY-Y0344D
Sodium chloride, for cell culture
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HY-Y0537E
Potassium chloride, for cell culture
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HY-W019981C
Magnesium chloride hexahydrate, for cell culture
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HY-D0858
MES
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HY-Y1110H
Magnesium chloride anhydrous, suitable for insect cell culture
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HY-Y0649
Lithium chloride, 99.3%-T
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HY-Y1110I
Magnesium chloride, for insect cell culture, 97%
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HY-W019981B
Magnesium chloride hexahydrate, for molecular biology
Biological Activity
Magnesium sulfate (3 mM) for cell culture inhibits phosphatidylinositol-4,5-bisphosphate-specific phospholipase C activity and subsequent calcium release in cultured myometrial cells[2].
Magnesium sulfate (20 mM; 6 h) for cell culture inhibits the LPS (HY-D1056)-induced inflammatory molecules production and NF-κB activation in RAW264.7 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 cells treated with 100 ng/mL of LPS (HY-D1056)
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Concentration:20 mM
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Incubation Time:6 h
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Result:Inhibtied the levels of iNOS and COX-2.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD-1 out-bred timed pregnant mice, and intrauterine inflammation was induced by intrauterine injection of LPS (HY-D1056) on embryonic day 15[4]
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Dosage:270 mg/kg, followed by 27 mg/kg every 20 minutes for 4 hours, and then an additional 270 mg/kg
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Administration:Intraperitoneal injection
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Result:Prevented LPS-induced neuronal injury in fetal mouse brains, as evidenced by maintaining normal neuronal morphology, including dendritic processes and MAP2 staining, without significantly affecting the expression of proinflammatory cytokines or cell death markers.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 7487-88-9
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Appearance Solid
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Molecular Weight 120.37
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Formula MgSO4
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Color White to off-white
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SMILES
[Mg]=S(O[O])([O])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : ≥ 100 mg/mL (830.77 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Ramsey PS, et al. Magnesium sulfate as a tocolytic agent. Semin Perinatol. 2001;25(4):236-247. [Content Brief]
[2]. Hurd WW, et al. Magnesium sulfate inhibits the oxytocin-induced production of inositol 1,4,5-trisphosphate in cultured human myometrial cells. Am J Obstet Gynecol. 2002 Aug;187(2):419-24. [Content Brief]
[3]. Lin CY, et al. L-type calcium channels are involved in mediating the anti-inflammatory effects of magnesium sulphate. Br J Anaesth. 2010 Jan;104(1):44-51. [Content Brief]
[4]. Burd I, et al. Magnesium sulfate reduces inflammation-associated brain injury in fetal mice. Am J Obstet Gynecol. 2010 Mar;202(3):292.e1-9. [Content Brief]
[5]. Okusanya BO, et al. Clinical pharmacokinetic properties of magnesium sulphate in women with pre-eclampsia and eclampsia. BJOG. 2016;123(3):356-366. [Content Brief]
[6]. Hunter LA, et al. Magnesium sulfate: past, present, and future. J Midwifery Womens Health. 2011 Nov-Dec;56(6):566-74. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 8.3077 mL | 41.5386 mL | 83.0772 mL | 207.6929 mL |
| 5 mM | 1.6615 mL | 8.3077 mL | 16.6154 mL | 41.5386 mL | |
| 10 mM | 0.8308 mL | 4.1539 mL | 8.3077 mL | 20.7693 mL | |
| 15 mM | 0.5538 mL | 2.7692 mL | 5.5385 mL | 13.8462 mL | |
| 20 mM | 0.4154 mL | 2.0769 mL | 4.1539 mL | 10.3846 mL | |
| 25 mM | 0.3323 mL | 1.6615 mL | 3.3231 mL | 8.3077 mL | |
| 30 mM | 0.2769 mL | 1.3846 mL | 2.7692 mL | 6.9231 mL | |
| 40 mM | 0.2077 mL | 1.0385 mL | 2.0769 mL | 5.1923 mL | |
| 50 mM | 0.1662 mL | 0.8308 mL | 1.6615 mL | 4.1539 mL | |
| 60 mM | 0.1385 mL | 0.6923 mL | 1.3846 mL | 3.4615 mL | |
| 80 mM | 0.1038 mL | 0.5192 mL | 1.0385 mL | 2.5962 mL | |
| 100 mM | 0.0831 mL | 0.4154 mL | 0.8308 mL | 2.0769 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Magnesium sulfate, for cell culture Related Classifications
HY-Y1267D Related Classifications
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