Lithium chloride, 99.3%-T
Based on 21 publication(s) in Google Scholar
Lithium chloride, 99% (LiCl, Premium grade) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
For research use only. We do not sell to patients.
- Purity: 99.57%
- CAS No.: 7447-41-8
- Formula: LiCl
- Molecular Weight:42.39
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Lithium chloride, 99.3%-T
More- Cell Discov. 2026 Feb 10;12(1):11. [Abstract]
- Cell Rep Med. 2026 Feb 17;7(2):102622. [Abstract]
- Cell Death Dis. 2021 Aug 21;12(9):802. [Abstract]
- Phytomedicine. 2026 Jul:156:158272. [Abstract]
- Phytomedicine. 2025 Dec 5:150:157676. [Abstract]
- J Transl Med. 2025 Jul 2;23(1):729. [Abstract]
- J Transl Med. 2025 Mar 19;23(1):350. [Abstract]
- Cell Rep. 2026 Jun 25;45(7):117613. [Abstract]
- Mech Ageing Dev. 2025 May 6:112067. [Abstract]
- Drug Des Devel Ther. 2026 May 12:20:585989. [Abstract]
- Bioorg Chem. 2026 Sep 5:179:110008. [Abstract]
- Cell Signal. 2025 Aug 29:136:112102. [Abstract]
- Oncol Res. 2025 Oct 22;33(11):3583-3603. [Abstract]
- Biol Trace Elem Res. 2025 May 29. [Abstract]
- Funct Integr Genomics. 2026 Feb 10;26(1):42. [Abstract]
- Pathol Res Pract. 2022 Apr:232:153829. [Abstract]
- Tissue Cell. 2025 Aug 18:97:103094. [Abstract]
- Clin Exp Pharmacol Physiol. 2026 Jan;53(1):e70096. [Abstract]
- Med Sci Monit. 2020 Aug 7:26:e925298. [Abstract]
- J Burn Care Res. 2025 Apr 8:iraf040. [Abstract]
- SSRN. 2025 Dec 1.
Customer Validation & Images
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Cell Migration/Invasion Assay
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IP
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Cell Migration/Invasion Assay
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WB
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Cell Proliferation/Viability Assay
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
>3000 μM
Compound: LiCl
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Effective concentration of compound against glycogen synthase kinase-3 in HEK293 cells
Effective concentration of compound against glycogen synthase kinase-3 in HEK293 cells
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[PMID: 15149684] |
| NB-4 | IC50 |
5.32 mM
Compound: LiCl
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Cytotoxicity against human NB-4 cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
Cytotoxicity against human NB-4 cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
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[PMID: 34027661] |
| NB4-DR1 | IC50 |
42.5 mM
Compound: LiCl
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Antiproliferative activity against human NB4-DR1 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human NB4-DR1 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
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[PMID: 34027661] |
GSK3β inhibitor
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 7447-41-8
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Appearance Solid
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Molecular Weight 42.39
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Formula LiCl
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Color White to off-white
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SMILES
[Li]Cl
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Synonyms
LiCl, Premium grade
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (21)
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Journal Impact Factor
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Most Recent
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Cell Discov
2026 Feb 10;12(1):11. PMID: 41663379 -
Cell Rep Med
A human patient-derived organoid biobank to model tumor heterogeneity and therapeutic vulnerability for oral squamous cell carcinoma. [Abstract]2026 Feb 17;7(2):102622. PMID: 41707653 -
Cell Death Dis
Hsa_circ_0026628 promotes the development of colorectal cancer by targeting SP1 to activate the Wnt/β-catenin pathway. [Abstract]2021 Aug 21;12(9):802. PMID: 34420031 -
Phytomedicine
Ginsenoside Rg3 improves atezolizumab immune checkpoint therapy in triple-negative breast cancer by targeting FUT8-mediated PD-L1 N-glycosylation. [Abstract]2026 Jul:156:158272. PMID: 42102789 -
Phytomedicine
Identification of key anti-pulmonary fibrosis components in Hyssopus cuspidatus Boriss. and its mechanism exploration. [Abstract]2025 Dec 5:150:157676. PMID: 41389405 -
J Transl Med
2025 Jul 2;23(1):729. PMID: 40605005
Lithium chloride, 99.3%-T purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Jul 2;23(1):729. [Abstract]
After DSG3 knockdown, the GSK3β inhibitor LiCl (10 mM, 24 h) was applied and the level of β-catenin ubiquitination was subsequently assessed.
Lithium chloride, 99.3%-T purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Jul 2;23(1):729. [Abstract]
β-catenin nuclear translocation was measured following DSG3 knockdown and LiCl (10 mM, 24 h) application.
Lithium chloride, 99.3%-T purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Jul 2;23(1):729. [Abstract]
Plate colony formation assay was conducted to evaluate the effect of LiCl (10 mM, 24 h) on the proliferation of 5637 cells post-DSG3 knockdown.
Lithium chloride, 99.3%-T purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Jul 2;23(1):729. [Abstract]
Transwell assays were performed to assess the effects of LiCl (10 mM, 24 h) on the invasion and migration of 5637 cells after DSG3 knockdown.
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J Transl Med
TMEM176B inhibits ovarian cancer progression by regulating EMT via the Wnt/β-catenin signaling pathway. [Abstract]2025 Mar 19;23(1):350. PMID: 40108613
Lithium chloride, 99.3%-T purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Mar 19;23(1):350. [Abstract]
The effect of LiCl (10 mM, 24 h) on the migration was assessed by wound healing assays.
Lithium chloride, 99.3%-T purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Mar 19;23(1):350. [Abstract]
The impact of LiCl (10 mM, 24 h) on the metastasis was evaluated using transwell assay.
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Cell Rep
Type I unconventional protein secretion of the SARS-CoV-2 nucleocapsid protein promotes inflammatory cytokine release. [Abstract]2026 Jun 25;45(7):117613. PMID: 42360880 -
Mech Ageing Dev
Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt/β-catenin signaling pathways. [Abstract]2025 May 6:112067. PMID: 40339921 -
Drug Des Devel Ther
GBVAM as a Novel NHE1 Inhibitor Alleviates Doxorubicin-Induced Cardiotoxicity via PI3K/Akt/mTOR Pathway. [Abstract]2026 May 12:20:585989. PMID: 42148365 -
Bioorg Chem
Euphorbia factor L3 ameliorates hepatic steatosis by activating LKB1-AMPK signaling pathway-regulated lipid metabolism. [Abstract]2026 Sep 5:179:110008. PMID: 42176359 -
Cell Signal
The RNA-binding protein Quaking modulates cell proliferation through the SFRP1 mediated Wnt signaling pathway in NIH3T3 fibroblasts. [Abstract]2025 Aug 29:136:112102. PMID: 40886927 -
Oncol Res
MINDY1 Induces PD-L1 Deubiquitination to Promote Immune Escape in Hepatocellular Carcinoma by the Wnt/β-Catenin Pathway. [Abstract]2025 Oct 22;33(11):3583-3603. PMID: 41179305 -
Biol Trace Elem Res
Wnt/β-catenin Pathway Activation Reverses Tau Hyperphosphorylation and β-Amyloid Accumulation Induced by Combined Manganese and Iron Exposure in PC12 Cells. [Abstract]2025 May 29. PMID: 40442456 -
Funct Integr Genomics
Honokiol attenuates renal fibrosis via SIRT3-Mediated regulation of Wnt/β-Catenin signaling. [Abstract]2026 Feb 10;26(1):42. PMID: 41663594 -
Pathol Res Pract
LncRNA OIP5-AS1 aggravates the stemness of hepatoblastoma through recruiting PTBP1 to increase the stability of β-catenin. [Abstract]2022 Apr:232:153829. PMID: 35255389 -
Tissue Cell
ATF5 inhibits autophagy and the Wnt/β-catenin pathway by upregulating mTOR to suppress the stemness of liver cancer stem cells. [Abstract]2025 Aug 18:97:103094. PMID: 40857870 -
Clin Exp Pharmacol Physiol
Esculin Facilitates Aerobic Glycolysis via the Wnt/β-Catenin/HIF-1α Pathway to Reduce the Progression of Gastric Cancer. [Abstract]2026 Jan;53(1):e70096. PMID: 41340325 -
Med Sci Monit
Reelin Promotes Cisplatin Resistance by Induction of Epithelial-Mesenchymal Transition via p38/GSK3β/Snail Signaling in Non-Small Cell Lung Cancer. [Abstract]2020 Aug 7:26:e925298. PMID: 32764530 -
J Burn Care Res
Pirfenidone ameliorates hypertrophic scar through inhibiting proliferation and migration of fibroblasts by regulating the Wnt/GSK-3β/β-catenin signaling pathway. [Abstract]2025 Apr 8:iraf040. PMID: 40203122 -
Solvent & Solubility
H2O : ≥ 100 mg/mL (2359.05 mM)
DMSO : 25 mg/mL (589.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 23.5905 mL | 117.9523 mL | 235.9047 mL | 589.7617 mL |
| 5 mM | 4.7181 mL | 23.5905 mL | 47.1809 mL | 117.9523 mL | |
| 10 mM | 2.3590 mL | 11.7952 mL | 23.5905 mL | 58.9762 mL | |
| 15 mM | 1.5727 mL | 7.8635 mL | 15.7270 mL | 39.3174 mL | |
| 20 mM | 1.1795 mL | 5.8976 mL | 11.7952 mL | 29.4881 mL | |
| 25 mM | 0.9436 mL | 4.7181 mL | 9.4362 mL | 23.5905 mL | |
| 30 mM | 0.7863 mL | 3.9317 mL | 7.8635 mL | 19.6587 mL | |
| 40 mM | 0.5898 mL | 2.9488 mL | 5.8976 mL | 14.7440 mL | |
| 50 mM | 0.4718 mL | 2.3590 mL | 4.7181 mL | 11.7952 mL | |
| 60 mM | 0.3932 mL | 1.9659 mL | 3.9317 mL | 9.8294 mL | |
| 80 mM | 0.2949 mL | 1.4744 mL | 2.9488 mL | 7.3720 mL | |
| 100 mM | 0.2359 mL | 1.1795 mL | 2.3590 mL | 5.8976 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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