1. Epigenetics
    PI3K/Akt/mTOR
  2. AMPK
  3. IQZ23

IQZ23 

Cat. No.: HY-133556
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IQZ23 inhibits adipocyte differentiation via AMPK pathway activation. IQZ23 exerts a high efficacy in decreasing the triglyceride level (EC50=0.033 μM) in 3T3-L1 adipocytes. IQZ23 could be used for the research of obesity and related metabolic disorders.

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IQZ23 Chemical Structure

IQZ23 Chemical Structure

CAS No. : 2415643-79-5

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Description

IQZ23 inhibits adipocyte differentiation via AMPK pathway activation. IQZ23 exerts a high efficacy in decreasing the triglyceride level (EC50=0.033 μM) in 3T3-L1 adipocytes. IQZ23 could be used for the research of obesity and related metabolic disorders[1].

IC50 & Target

AMPK

 

In Vitro

IQZ23 activates AMPK pathway by modulating ATP synthase activity[1].
IQZ23 (0.3 and 1.0 μM) markedly decreases the protein level of adipogenic factors C/EBPα, PPARγ, and sterol regulatory element-binding protein 1c (SREBP-1c)) after 24 h treatment as well as the level of fatty acid synthesis related proteins fatty acid synthase (FAS), acetyl CoA carboxylase (ACC), stearoyl-CoA desaturase 1 (SCD1) after 6 days of treatment in 3T3-L1 adipocytes[1].

Western Blot Analysis[1]

Cell Line: 3T3-L1 adipocytes
Concentration: 0.3 and 1.0 μM
Incubation Time: 24 hours
Result: Decreased the protein level of adipogenic factors C/EBPα, PPARγ, and SREBP-1c.
In Vivo

IQZ23 (20 mg/kg, i.p.) treatment significantly reverses high fat and cholesterol diet (HFC)- induced body weight increases and accompanying clinical symptoms of obesity in mice but without indicative toxicity[1].
IQZ23 exhibits moderate terminal elimination half-lives (rat 4.2±0.3 h) and Cmax (rat 37.1±7.0 ng/mL) following oral administration (rat 5 mg/kg)[1].
IQZ23 exhibits terminal elimination half-lives (rat 4.4±0.4 h) following intravenous administration (rat 2 mg/kg)[1].

Molecular Weight

443.54

Formula

C₂₆H₂₉N₅O₂

CAS No.

2415643-79-5

SMILES

COC1=CC=C(NC(C2=NC(C=CC=C3)=C3C(NCCCCN4CCCC4)=N2)=C5C=O)C5=C1

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Keywords:

IQZ23IQZ 23IQZ-23AMPKAMP-activated protein kinaseadipocytedifferentiationtriglyceride3T3-L1obesitymetabolicdisordersInhibitorinhibitorinhibit

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IQZ23
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HY-133556
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