2. Metabolic Enzyme/Protease PI3K/Akt/mTOR Epigenetics MAPK/ERK Pathway
  3. FBPase AMPK mTOR Ribosomal S6 Kinase (RSK)
  4. FBPase-IN-6

FBPase-IN-6 (Compound 96) is an orally active FBPase inhibitor with an IC50 value of 1.769 μM. FBPase-IN-6 modulates AMPK/mTORC1/S6K signaling pathways. FBPase-IN-6 improves glucose tolerance, enhances insulin sensitivity, and promotes insulin secretion in type 2 diabetic mice.

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FBPase-IN-6

FBPase-IN-6 Chemical Structure

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FBPase-IN-6 Related Antibodies

Top Publications Citing Use of Products

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

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mTOR mTORC1 mTORC2

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p70S6K RSK2 RSK3 RSK4

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Description

FBPase-IN-6 (Compound 96) is an orally active FBPase inhibitor with an IC50 value of 1.769 μM. FBPase-IN-6 modulates AMPK/mTORC1/S6K signaling pathways. FBPase-IN-6 improves glucose tolerance, enhances insulin sensitivity, and promotes insulin secretion in type 2 diabetic mice[1].

IC50 & Target[1]

mTORC1

 

Molecular Weight

513.99

Formula

C25H24ClN3O5S
SMILES

COC1=CC=CC(NC2=C3C(N(C)C(C(N(C)S(C4=CC=C(OC)C=C4)(=O)=O)=O)=C3)=C(Cl)C=C2)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FBPase-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FBPase-IN-6FBPaseAMPKmTORRibosomal S6 Kinase (RSK)fructose-1,6-bisphosphataseAMP-activated protein kinaseMammalian target of RapamycinS6Ktype 2 diabeticInhibitorinhibitorinhibit

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