Chromium(III) acetate
Based on 2 publication(s) in Google Scholar
Chromium(III) acetate (Chromic acetate) is an AMPK inhibitor that promotes lipogenesis by inhibiting AMPK phosphorylation. Chromium(III) acetate has low toxicity in mammals, with an LD50 of 2365 mg/kg in rats.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.9%
- CAS 番号: 1066-30-4
- 分子式: Cr(CH3COO)3
- 分子量:229.13
-
保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-N0583
HydrocortisoneGlucocorticoid Receptor Agonist -
HY-Y0319B
Acetic acid (potassium 99%)Potassium Salt -
HY-Y0319B1
Potassium acetate, for molecular biologyAcetate Salt -
HY-Y0756
Sodium bicarbonateInorganic Salt -
HY-W251598C
Sodium bicarbonate, for cell cultureInorganic Salt -
HY-W088074A
Chromium(III)oxide, 99.9% trace metals basisBiochemical Assay Reagent -
HY-W251598B
Sodium bicarbonate, for molecular biologyInorganic Salt -
HY-125588
Chromium picolinateInsulin Resistance Reducer -
HY-D0833
Tricalcium phosphateCalcium-phosphorus Compound -
HY-Y0319B2
Potassium acetate, meets USP testing specificationsInorganic salt -
HY-Y0319B3
Potassium acetate, meets analytical specification of Ph. Eur. BP E261Biochemical Assay Reagent -
HY-149303
Potassium tert-butoxideBiochemical Reagent
MedChemExpress（MCE）の使用を引用している文献 Chromium(III) acetate
MoreAMPK アイソフォーム固有の製品をすべて表示
More
生物活性
製品説明
体外実験
Chromium(III) acetate (0.1-10 μM，96 h) stimulates adipogenesis through regulation of gene expression and phosphorylation of adenosine monophosphate-activated protein kinase in bovine intramuscular or subcutaneous adipocytes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Bovine intramuscular(IM) preadipocytes, Bovine subcutaneous(SC) preadipocytes
-
Concentration:0.1, 1, 10 μM
-
Incubation Time:96 h
-
Result:Reduced the ratio of phosphorylated AMPKα to AMPKα.
-
Cell Line:Bovine intramuscular(IM) preadipocytes, Bovine subcutaneous(SC) preadipocytes
-
Concentration:0.1, 1, 10 μM
-
Incubation Time:96 h
-
Result:Upregulate the mRNA levels of adipogenic transcription factors C/EBPβ, PPARγ, and SCD in bovine IM adipocytes (10 μM). Downregulates AMPKα gene expression and upregulates C/EBPβ and SCD gene expression (10 μM) in bovine SC adipocytes.
化学情報
-
CAS 番号 1066-30-4
-
性状 Solid
-
分子量 229.13
-
分子式 Cr(CH3COO)3
-
Color Light green to green
-
SMILES
C[Cr](C)C.O=C=O.O=C=O.O=C=O
-
別名
Chromium acetate; Chromic acetate; Chromium triacetate
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
-
Journal Impact Factor
-
Most Recent
溶剤 & 溶解度
体外:
DMSO : 12.5 mg/mL (54.55 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (5.46 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (5.46 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
-
データシート (275 KB)
-
SDS (422 KB)
- English - EN (422 KB)
- Français - FR (422 KB)
- Deutsch - DE (422 KB)
- Norwegian - NO (422 KB)
- Español - ES (422 KB)
- Swedish - SV (422 KB)
- Italian - IT (422 KB)
- Korean - KR (422 KB)
- Portuguese - PT (422 KB)
-
取扱説明書 (2659 KB)
参考文献
[2]. Kim J, et al. Chromium acetate stimulates adipogenesis through regulation of gene expression and phosphorylation of adenosine monophosphate-activated protein kinase in bovine intramuscular or subcutaneous adipocytes[J]. Asian-Australasian journal of animal sciences, 2020, 33(4): 651. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.3643 mL | 21.8217 mL | 43.6433 mL | 109.1084 mL |
| 5 mM | 0.8729 mL | 4.3643 mL | 8.7287 mL | 21.8217 mL | |
| 10 mM | 0.4364 mL | 2.1822 mL | 4.3643 mL | 10.9108 mL | |
| 15 mM | 0.2910 mL | 1.4548 mL | 2.9096 mL | 7.2739 mL | |
| 20 mM | 0.2182 mL | 1.0911 mL | 2.1822 mL | 5.4554 mL | |
| 25 mM | 0.1746 mL | 0.8729 mL | 1.7457 mL | 4.3643 mL | |
| 30 mM | 0.1455 mL | 0.7274 mL | 1.4548 mL | 3.6369 mL | |
| 40 mM | 0.1091 mL | 0.5455 mL | 1.0911 mL | 2.7277 mL | |
| 50 mM | 0.0873 mL | 0.4364 mL | 0.8729 mL | 2.1822 mL |
Chromium(III) acetate 関連分類
HY-D1163 関連分類
Powered by Bioz