Chromium(III) acetate
Based on 2 publication(s) in Google Scholar
Chromium(III) acetate (Chromic acetate) is an AMPK inhibitor that promotes lipogenesis by inhibiting AMPK phosphorylation. Chromium(III) acetate has low toxicity in mammals, with an LD50 of 2365 mg/kg in rats.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 1066-30-4
- Formula: Cr(CH3COO)3
- Molecular Weight:229.13
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Chromium(III) acetate
MoreAll AMPK Isoforms
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Biological Activity
Chromium(III) acetate (0.1-10 μM，96 h) stimulates adipogenesis through regulation of gene expression and phosphorylation of adenosine monophosphate-activated protein kinase in bovine intramuscular or subcutaneous adipocytes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Bovine intramuscular(IM) preadipocytes, Bovine subcutaneous(SC) preadipocytes
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Concentration:0.1, 1, 10 μM
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Incubation Time:96 h
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Result:Reduced the ratio of phosphorylated AMPKα to AMPKα.
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Cell Line:Bovine intramuscular(IM) preadipocytes, Bovine subcutaneous(SC) preadipocytes
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Concentration:0.1, 1, 10 μM
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Incubation Time:96 h
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Result:Upregulate the mRNA levels of adipogenic transcription factors C/EBPβ, PPARγ, and SCD in bovine IM adipocytes (10 μM). Downregulates AMPKα gene expression and upregulates C/EBPβ and SCD gene expression (10 μM) in bovine SC adipocytes.
Chemical Information
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CAS No. 1066-30-4
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Appearance Solid
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Molecular Weight 229.13
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Formula Cr(CH3COO)3
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Color Light green to green
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SMILES
C[Cr](C)C.O=C=O.O=C=O.O=C=O
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Synonyms
Chromium acetate; Chromic acetate; Chromium triacetate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 12.5 mg/mL (54.55 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (5.46 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (5.46 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (422 KB)
- English - EN (422 KB)
- Français - FR (422 KB)
- Deutsch - DE (422 KB)
- Norwegian - NO (422 KB)
- Español - ES (422 KB)
- Swedish - SV (422 KB)
- Italian - IT (422 KB)
- Korean - KR (422 KB)
- Portuguese - PT (422 KB)
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Handling Instructions (2659 KB)
References
[2]. Kim J, et al. Chromium acetate stimulates adipogenesis through regulation of gene expression and phosphorylation of adenosine monophosphate-activated protein kinase in bovine intramuscular or subcutaneous adipocytes[J]. Asian-Australasian journal of animal sciences, 2020, 33(4): 651. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.3643 mL | 21.8217 mL | 43.6433 mL | 109.1084 mL |
| 5 mM | 0.8729 mL | 4.3643 mL | 8.7287 mL | 21.8217 mL | |
| 10 mM | 0.4364 mL | 2.1822 mL | 4.3643 mL | 10.9108 mL | |
| 15 mM | 0.2910 mL | 1.4548 mL | 2.9096 mL | 7.2739 mL | |
| 20 mM | 0.2182 mL | 1.0911 mL | 2.1822 mL | 5.4554 mL | |
| 25 mM | 0.1746 mL | 0.8729 mL | 1.7457 mL | 4.3643 mL | |
| 30 mM | 0.1455 mL | 0.7274 mL | 1.4548 mL | 3.6369 mL | |
| 40 mM | 0.1091 mL | 0.5455 mL | 1.0911 mL | 2.7277 mL | |
| 50 mM | 0.0873 mL | 0.4364 mL | 0.8729 mL | 2.1822 mL |
Chromium(III) acetate Related Classifications
HY-D1163 Related Classifications
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