2. Neuronal Signaling Metabolic Enzyme/Protease PI3K/Akt/mTOR Epigenetics Apoptosis Autophagy
  3. CaMK MMP AMPK Apoptosis Autophagy
  4. Fluoxetine-Conjugated Platinum(IV) prodrug-1

Fluoxetine-Conjugated Platinum(IV) prodrug-1 (Compound 8) is an eEF2K inhibitor. Fluoxetine-Conjugated Platinum(IV) prodrug-1 inhibits cancer cell proliferation, induces DNA damage, cell cycle arrest at S phase and apoptosis. Fluoxetine-Conjugated Platinum(IV) prodrug-1 induces ROS accumulation and mitochondrial dysfunction. Fluoxetine-Conjugated Platinum(IV) prodrug-1 inhibits TNBC cell migration and invasion by inhibiting MMP-2 activity. Fluoxetine-Conjugated Platinum(IV) prodrug-1 induces autophagy in TNBC cells by activating AMPK. Fluoxetine-Conjugated Platinum(IV) prodrug-1 has antitumor activity and activates immunosuppression in the 4T1-Luc mouse model. Fluoxetine-Conjugated Platinum(IV) prodrug-1 can be used in triple-negative breast cancer (TNBC) research.

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Fluoxetine-Conjugated Platinum(IV) prodrug-1

Fluoxetine-Conjugated Platinum(IV) prodrug-1 Estructura química

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Fluoxetine-Conjugated Platinum(IV) prodrug-1 Related Antibodies

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CaMK II CaMK III/eEF-2K CAMK IV PHK Trio DCAMKL

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

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Descripciòn

Fluoxetine-Conjugated Platinum(IV) prodrug-1 (Compound 8) is an eEF2K inhibitor. Fluoxetine-Conjugated Platinum(IV) prodrug-1 inhibits cancer cell proliferation, induces DNA damage, cell cycle arrest at S phase and apoptosis. Fluoxetine-Conjugated Platinum(IV) prodrug-1 induces ROS accumulation and mitochondrial dysfunction. Fluoxetine-Conjugated Platinum(IV) prodrug-1 inhibits TNBC cell migration and invasion by inhibiting MMP-2 activity. Fluoxetine-Conjugated Platinum(IV) prodrug-1 induces autophagy in TNBC cells by activating AMPK. Fluoxetine-Conjugated Platinum(IV) prodrug-1 has antitumor activity and activates immunosuppression in the 4T1-Luc mouse model. Fluoxetine-Conjugated Platinum(IV) prodrug-1 can be used in triple-negative breast cancer (TNBC) research[1].

Peso molecular

725.45

Fòrmula

C21H28Cl2F3N3O5Pt
SMILES

[NH3][Pt]([NH3])(OC(CCC(N(CCC(OC1=CC=C(C=C1)C(F)(F)F)C2=CC=CC=C2)C)=O)=O)(O)(Cl)Cl
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Room temperature in continental US; may vary elsewhere.
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Fluoxetine-Conjugated Platinum(IV) prodrug-1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fluoxetine-Conjugated Platinum(IV) prodrug-1CaMKMMPAMPKApoptosisAutophagyCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesMatrix metalloproteinasesAMP-activated protein kinaseTNBCMDA-MB-231MCF-7A549HCT-116HeLaHepG2LO24T1-Luc mouse modeltumorcancerInhibitorinhibitorinhibit

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Nombre del producto:
Fluoxetine-Conjugated Platinum(IV) prodrug-1
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HY-176149
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