PF-07293893
Based on 1 Customer Validation
PF-07293893 is an AMPKγ3 activator. PF-07293893 increases glycogen content, improves lipid oxidation, enhances mitochondrial biogenesis and promotes vascular repair. PF-07293893 is applicable to research related to heart failure.
For research use only. We do not sell to patients.
- Purity: 99.96%
- CAS No.: 3036759-47-1
- Formula: C26H23ClF4N6O2
- Molecular Weight:562.95
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All AMPK Isoforms
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Biological Activity
PF-07293893 selectively activates the γ3 subunit, which can increase glycogen content and lipid oxidation, improve mitochondrial biosynthesis, and promote vascular repair[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 3036759-47-1
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Appearance Solid
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Molecular Weight 562.95
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Formula C26H23ClF4N6O2
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Color White to off-white
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SMILES
CN1C=C(C(N2C[C@](C3=CC=CC(Cl)=C3F)(C4=C(C(NC5CN(C5)C([C@@H]6C[C@@H]6F)=O)=NC=C4C2=O)F)C)=N1)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (177.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7764 mL | 8.8818 mL | 17.7636 mL | 44.4089 mL |
| 5 mM | 0.3553 mL | 1.7764 mL | 3.5527 mL | 8.8818 mL | |
| 10 mM | 0.1776 mL | 0.8882 mL | 1.7764 mL | 4.4409 mL | |
| 15 mM | 0.1184 mL | 0.5921 mL | 1.1842 mL | 2.9606 mL | |
| 20 mM | 0.0888 mL | 0.4441 mL | 0.8882 mL | 2.2204 mL | |
| 25 mM | 0.0711 mL | 0.3553 mL | 0.7105 mL | 1.7764 mL | |
| 30 mM | 0.0592 mL | 0.2961 mL | 0.5921 mL | 1.4803 mL | |
| 40 mM | 0.0444 mL | 0.2220 mL | 0.4441 mL | 1.1102 mL | |
| 50 mM | 0.0355 mL | 0.1776 mL | 0.3553 mL | 0.8882 mL | |
| 60 mM | 0.0296 mL | 0.1480 mL | 0.2961 mL | 0.7401 mL | |
| 80 mM | 0.0222 mL | 0.1110 mL | 0.2220 mL | 0.5551 mL | |
| 100 mM | 0.0178 mL | 0.0888 mL | 0.1776 mL | 0.4441 mL |
PF-07293893 Related Classifications
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