2. Epigenetics PI3K/Akt/mTOR
  3. AMPK
  4. PF-07293893

PF-07293893 is an AMPKγ3 activator. PF-07293893 increases glycogen content, improves lipid oxidation, enhances mitochondrial biogenesis and promotes vascular repair. PF-07293893 is applicable to research related to heart failure.

For research use only. We do not sell to patients.

PF-07293893

PF-07293893 Chemical Structure

CAS No. : 3036759-47-1

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Based on 1 publication(s) in Google Scholar

PF-07293893 Related Antibodies

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

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Description

PF-07293893 is an AMPKγ3 activator. PF-07293893 increases glycogen content, improves lipid oxidation, enhances mitochondrial biogenesis and promotes vascular repair. PF-07293893 is applicable to research related to heart failure[1].

In Vitro

PF-07293893 selectively activates the γ3 subunit, which can increase glycogen content and lipid oxidation, improve mitochondrial biosynthesis, and promote vascular repair[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PF-07293893 Related Antibodies
Clinical Trial
Molecular Weight

562.95

Formula

C26H23ClF4N6O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN1C=C(C(N2C[C@](C3=CC=CC(Cl)=C3F)(C4=C(C(NC5CN(C5)C([C@@H]6C[C@@H]6F)=O)=NC=C4C2=O)F)C)=N1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (177.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7764 mL 8.8818 mL 17.7636 mL
5 mM 0.3553 mL 1.7764 mL 3.5527 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7764 mL 8.8818 mL 17.7636 mL 44.4089 mL
5 mM 0.3553 mL 1.7764 mL 3.5527 mL 8.8818 mL
10 mM 0.1776 mL 0.8882 mL 1.7764 mL 4.4409 mL
15 mM 0.1184 mL 0.5921 mL 1.1842 mL 2.9606 mL
20 mM 0.0888 mL 0.4441 mL 0.8882 mL 2.2204 mL
25 mM 0.0711 mL 0.3553 mL 0.7105 mL 1.7764 mL
30 mM 0.0592 mL 0.2961 mL 0.5921 mL 1.4803 mL
40 mM 0.0444 mL 0.2220 mL 0.4441 mL 1.1102 mL
50 mM 0.0355 mL 0.1776 mL 0.3553 mL 0.8882 mL
60 mM 0.0296 mL 0.1480 mL 0.2961 mL 0.7401 mL
80 mM 0.0222 mL 0.1110 mL 0.2220 mL 0.5551 mL
100 mM 0.0178 mL 0.0888 mL 0.1776 mL 0.4441 mL
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PF-07293893 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-072938933036759-47-1PF07293893PF 07293893AMPKAMP-activated protein kinaseglycogen contentmitochondrial biogenesisadenosine monophosphate-activated protein kinase γ3 subunitvascular restorationlipid oxidationheart failure with preserved ejection fractionAMPKγ3Inhibitorinhibitorinhibit

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