AR493
AR493 is an autophagy activator acting on AMPK (adenosine monophosphate-activated protein kinase). AR493 regulates pathways related to cellular energy sensing and increases autophagy levels. AR493 is promising for research of aging-associated diseases (such as diabetes, neurodegenerative diseases) and autophagy regulation.
For research use only. We do not sell to patients.
- CAS No.: 1290546-06-3
- Formula: C16H17N3O5
- Molecular Weight:331.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All AMPK Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEL | CC50 |
>100 μM
Compound: 12d
|
Cytotoxicity against human HEL cells assessed as reduction in cell viability measured after 3 days by beckman coulter counting method
Cytotoxicity against human HEL cells assessed as reduction in cell viability measured after 3 days by beckman coulter counting method
|
[PMID: 33894564] |
| HEp-2 | CC50 |
>100 μM
Compound: 12d
|
Cytotoxicity in human Hep2 cells assessed as reduction in cell viability measured after 3 days by beckman coulter counting method
Cytotoxicity in human Hep2 cells assessed as reduction in cell viability measured after 3 days by beckman coulter counting method
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[PMID: 33894564] |
| MDCK | CC50 |
>100 μM
Compound: 12d
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Cytotoxicity in dog MDCK cells assessed as reduction in cell viability measured after 3 days by beckman coulter counting method
Cytotoxicity in dog MDCK cells assessed as reduction in cell viability measured after 3 days by beckman coulter counting method
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[PMID: 33894564] |
| Vero | CC50 |
>100 μM
Compound: 12d
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Cytotoxicity in African green monkey Vero cells assessed as reduction in cell viability measured after 5 days by resazurin dye based assay
Cytotoxicity in African green monkey Vero cells assessed as reduction in cell viability measured after 5 days by resazurin dye based assay
|
[PMID: 33894564] |
Chemical Information
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CAS No. 1290546-06-3
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Molecular Weight 331.32
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Formula C16H17N3O5
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SMILES
CN(C1=CC=CC=C1OC2=CN3[C@H]4C[C@H](O)[C@@H](CO)O4)C2=NC3=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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