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acly

" in MedChemExpress (MCE) Product Catalog:

643

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24

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23

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236

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1

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5

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39

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3

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19

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56

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P1098
    Ac2-26
    5+ Cited Publications

    		 Annexin A NF-κB Inflammation/Immunology
    Ac2-26 is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ameliorates lung ischemia-reperfusion injury. Ac2-26 also inhibits airway inflammation and hyperresponsiveness in an asthma rat model .
    Ac2-26
  • HY-110288
    3FAx-Neu5Ac
    3 Publications Verification

    		 Sialyltransferase Metabolic Disease
    3FAx-Neu5Ac (Compound 8), a Sialic acid peracetylated analog, is a sialyltransferase inhibitor. 3FAx-Neu5Ac substantially reduces expression of the sialylated ligand sialyl Lewis X .
    3FAx-Neu5Ac
  • HY-122214
    AC-73
    5+ Cited Publications

    		 Autophagy Cancer
    AC-73 is a first specific, orally active inhibitor of cluster of differentiation 147 (CD147), which specifically disrupts CD147 dimerization, thereby mainly suppressing the CD147/ERK1/2/STAT3/MMP-2 pathways. AC-73 inhibits the motility and invasion of hepatocellular carcinoma cells . AC-73 is also an anti-proliferative agent and an inducer of autophagy in leukemic cells .
    AC-73
  • HY-175606
    EVT0185

    		ATP Citrate Lyase Cancer
    EVT0185 is an orally active ATP citrate lyase (ACLY) inhibitor. EVT0185 is converted to a CoA thioester in the liver by SLC27A2 and interacts with the CoA-binding site of ACLY. EVT0185-CoA inhibits ACLY activity with an IC50 of 2.5 μM. EVT0185 can phenocopy the immune and antitumour effects of genetic ACLY deletion. EVT0185 can increase tumour-infiltrating B cells and chemokine CXCL13 levels. EVT0185 can be used for the research of cancer, such as hepatocellular carcinoma (HCC) .
    EVT0185
  • HY-124500
    AC-4-130
    5+ Cited Publications

    		 STAT Apoptosis Cancer
    AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML) .
    AC-4-130
  • HY-122025
    AC-262536
    1 Publications Verification

    		 Androgen Receptor Metabolic Disease
    AC-262536 is a selective and non-steroidal androgen receptor modulators (SARMs) with beneficial anabolic effects. AC-262536 exhibits potent agonist activity at the androgen receptor, with an affinity in the low nanomolar range (1-10 nM) .
    AC-262536
  • HY-B0491A
    Carbazochrome sodium sulfonate

    AC-17

    		 Adrenergic Receptor Cardiovascular Disease
    Carbazochrome sodium sulfonate (AC-17) is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome sodium sulfonate is an antihemorrhagic agent .
    Carbazochrome sodium sulfonate
  • HY-103195
    NKY80
    2 Publications Verification

    		 Adenylate Cyclase Metabolic Disease
    NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC50s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues .
    NKY80
  • HY-124004
    Acetyl-6-formylpterin

    Ac-6-FP

    		 Biochemical Assay Reagents Inflammation/Immunology
    Acetyl-6-formylpterin (Ac-6-FP) is a hapten that covalently binds to MR1 through residue Lys43 of the protein, resulting in protein upregulation. Acetyl-6-formylpterin (Ac-6-FP) can be used in the study of inflammation .
    Acetyl-6-formylpterin
  • HY-147286
    Ac-Lys-Val-Cit-PABC-MMAE

    		Drug-Linker Conjugates for ADC Cancer
    Ac-Lys-Val-Cit-PABC-MMAE is a agent-linker conjugate for ADC. Ac-Lys-Val-Cit-PABC-MMAE contains the ADC linker (peptide Ac-Lys-Val-Cit-PABC) and a potent tubulin polymerization inhibitor MMAE (HY-15162) .
    Ac-Lys-Val-Cit-PABC-MMAE
  • HY-P1098A
    Ac2-26 TFA
    5+ Cited Publications

    		 Annexin A NF-κB Inflammation/Immunology
    Ac2-26 TFA is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ameliorates lung ischemia-reperfusion injury. Ac2-26 also inhibits airway inflammation and hyperresponsiveness in an asthma rat model .
    Ac2-26 TFA
  • HY-P11212
    Ac-RHKK(Ac)-AMC

    		Fluorescent Dye Metabolic Disease Cancer
    Ac-RHKK(Ac)-AMC (Compound S1) is a fluorescent substrate for SITR6, that is based on p53 sequence. Ac-RHKK(Ac)-AMC mimics H3K56 deacetylation site and significantly increases the deacetylation signal with low signal-to-background ratio. Ac-RHKK(Ac)-AMC can be used for ageing and cancers research .
    Ac-RHKK(Ac)-AMC
  • HY-W004066
    Ac-Ala-OH

    		Endogenous Metabolite Ser/Thr Protease Metabolic Disease Cancer
    Ac-Ala-OH is an endogenous metabolite. Ac-ALA-OH inhibits APEH. Ac-Ala-OH can be used in breast cancer research .
    Ac-Ala-OH
  • HY-116530
    9-Cyclopentyladenine monomethanesulfonate

    9-CP-Ade mesylate

    		 Adenylate Cyclase Others Neurological Disease
    9-Cyclopentyladenine monomethylsulfonate (9-CP-Ade mesylate) is a stable non-competitive adenylate cyclase inhibitor with cell permeable properties .
    9-Cyclopentyladenine monomethanesulfonate
  • HY-P2462
    Ac-Arg-Gly-Lys(Ac)-AMC

    		HDAC Others
    Ac-Arg-Gly-Lys(Ac)-AMC is a substrate for HDAC .
    Ac-Arg-Gly-Lys(Ac)-AMC
  • HY-110157
    AC-186

    		Estrogen Receptor/ERR Neurological Disease
    AC-186 is a selective non-steroidal estrogen receptor β (ERβ) agonist with EC50s of 6 nM and 5000 nM for ERβ and ERα, respectively. AC-186 shows gender selective neuroprotective effects in a male rat model of Parkinson's disease .
    AC-186
  • HY-W570884
    5-Me-dC(Ac) amidite

    		Phosphoramidites DNA/RNA Synthesis Others
    5-Me-dC(Ac) amidite is an acetyl (Ac)-modified nucleotide commonly used in the synthesis of modified oligonucleotides.
    5-Me-dC(Ac) amidite
  • HY-158783
    SACLAC

    		Ceramidase Bcl-2 Family LPL Receptor Apoptosis Neurological Disease
    SACLAC, a Ceramide analog, is a potent and covalent acid ceramidase (ASAH1; AC) inhibitor with a Ki of 97.1 nM. SACLAC effectively blocks AC activity and induces a decrease in sphingosine 1-phosphate (S1P) and total ceramide levels. SACLAC reduces the levels of splicing factor SF3B1 and alternative Mcl-1 mRNA splicing, increases pro-apoptotic Mcl-1S levels to induce apoptosis in acute myeloid leukemia (AML) cells. SACLAC reduces the leukemic burden in human AML xenograft mouse models .
    SACLAC
  • HY-124680
    AC-263093 free base

    AC-093

    		 Neuropeptide FF Receptor Inflammation/Immunology
    AC-263093 free base (AC-093) functionally activates NPFFR2 and blocks activation of NPFFR1 with pKis of 6.9 and 7.0, respectively. AC-263093 free base has the potential for reversing opiate tolerance research .
    .
    AC-263093 free base
  • HY-P1098B
    Ac2-26 ammonium
    5+ Cited Publications

    		 IKK Inflammation/Immunology
    Ac2-26 ammonium is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 ammonium induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ammonium ameliorates lung ischemia-reperfusion injury. Ac2-26 ammonium also inhibits airway inflammation and hyperresponsiveness in an asthma rat model .
    Ac2-26 ammonium
  • HY-18234C
    Leupeptin Ac-LL hydrochloride

    		Biochemical Assay Reagents Inflammation/Immunology Cancer
    Leupeptin Ac-LL (hydrochloride) is the hydrochloride form of Leupeptin Ac-LL (HY-18234B). Leupeptin Ac-LL (hydrochloride) has better inhibition than Leupeptin Ac-LL .
    Leupeptin Ac-LL hydrochloride
  • HY-118343
    AC-93253

    		Sirtuin Cancer
    AC-93253 is a selective, potent SIRT2 inhibitor. AC93253 can inhibit SIRT2 with an IC50 value of 6 μM. AC93253 can be used for the research of tumors .
    AC-93253
  • HY-136727
    Ac-LEVD-CHO
    1 Publications Verification

    		 Caspase Cancer
    Ac-LEVD-CHO is a caspase-4 inhibitor. Ac-LEVD-CHO is a peptide with the sequence of Ac-Leu-Glu-Val-Asp-al .
    Ac-LEVD-CHO
  • HY-172914
    ACLY-IN-1

    		ATP Citrate Lyase Cardiovascular Disease Metabolic Disease
    ACLY-IN-1 is an orally active ACLY inhibitor. ACLY-IN-1 exhibits potent ACLY inhibitory activity (IC50 = 8.3 nM) and high binding affinity (KD = 72.0 nM) to ACLY. ACLY-IN-1 demonstrates good pharmacokinetic profiles and a potent in vivo hypolipidemic effect .
    ACLY-IN-1
  • HY-RS00166
    ACLY Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ACLY Human Pre-designed siRNA Set A contains three designed siRNAs for ACLY gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ACLY Human Pre-designed siRNA Set A
    ACLY Human Pre-designed siRNA Set A
  • HY-16020
    AC-430 hydrobromide

    		JAK Cancer
    AC-430 hydrobromide (example 1) is a potent JAK2 inhibitor. AC-430 hydrobromide can be used for the research of myeloproliferative disorders and cancer .
    AC-430 hydrobromide
  • HY-145830
    AC1-IN-1

    		Adenylate Cyclase Neurological Disease
    AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC50 of 0.54 μM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain .
    AC1-IN-1
  • HY-149552
    Ac4-5SGlcNAc

    		OGT Cancer
    Ac4-5SGlcNAc is an O-GlcNAc transferase (OGT) inhibitor. Ac4-5SGlcNAc converts intracellularly to UDP-5SGlcNAc, which competes with native UDP-GlcNAc (HY-148596) to block OGT catalytic activity, reduces cellular UDP-GlcNAc pools, and limits global protein O-GlcNAcylation. Ac4-5SGlcNAc reduces OGA levels via feedback, alters lectin signal intensities and glycan-related band masses. Ac4-5SGlcNAc can be used for the research of breast cancer .
    Ac4-5SGlcNAc
  • HY-128919
    Ac-Lys-AMC

    		HDAC Others
    Ac-Lys-AMC (Hexanamide), also termed MAL, is a fluorescent substrate for histone deacetylase HDACs .
    Ac-Lys-AMC
  • HY-177136
    ACLY-IN-2

    		ATP Citrate Lyase Metabolic Disease Inflammation/Immunology Cancer
    ACLY-IN-2 (Compound 7) has inhibitory effect against human ATP citrate lyase (hACLY), with an IC50 of less than 1 nM. ACLY-IN-2 can be studied in research on liver-related diseases, type-2 diabetes, autoimmunity, and cancer .
    ACLY-IN-2
  • HY-118806A
    AC-42 hydrochloride

    		mAChR Neurological Disease
    AC-42 hydrochloride is the hydrochloride salt form of AC-42 (HY-118806). AC-42 hydrochloride is an allosteric agonist for muscarinic M1 receptor with EC50s of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively. AC-42 hydrochloride stimulates the inositol phosphate (IP)-accumulation and calcium mobilization in CHO cells .
    AC-42 hydrochloride
  • HY-P11213
    Ac-RYQK(Ac)-AMC

    		Fluorescent Dye Metabolic Disease Cancer
    Ac-RYQK(Ac)-AMC (Compound S5) is a fluorescent substrate for SITR6, that is based on the H3 sequence. Ac-RYQK(Ac)-AMC mimics H3K56 deacetylation site and significantly increases the deacetylation signal with superior signal-to-background ratio. Ac-RYQK(Ac)-AMC can be used for ageing and cancers research .
    Ac-RYQK(Ac)-AMC
  • HY-117851
    AC-265347

    		CaSR Metabolic Disease Endocrinology
    AC-265347 is a calcium-sensing receptor (CaSR) agonist and positive allosteric modulator (ago-PAM) with the functional affinity (pKB) of 5.1. AC-265347 can be used for the research of hyperparathyroidism and related diseases .
    AC-265347
  • HY-153613
    Ac-PLVE-FMK

    Ac-Pro-Leu-Val-Glu(OMe)-CH2F

    		 Cathepsin Cancer
    Ac-PLVE-FMK (Ac-Pro-Leu-Val-Glu(OMe)-CH2F), a tetrapeptidyl m-FMKs, is a Cats inhibitor. Ac-PLVE-FMK can be used for the research of cancer .
    Ac-PLVE-FMK
  • HY-N15826
    RBM1-151

    		Fluorescent Dye Ceramidase Cancer
    RBM1-151, a 1-deoxy derivative and vinilog of RBM14-C12 (HY-150163), as a fluorogenic substrate of Amidases (HY-P2736) (Ex/Em). RBM1-151 is hydrolyzed by acid ceramidase (AC) (( appKm = 7.0 μM; appVmax = 99.3 nM/min), N-acylethanolamine-hydrolyzing acid amidase ( appKm = 0.73 μM; appVmax = 0.24 nM/min), and fatty Acid amide hydrolase (FAAH) ( appKm = 3.6 μM; appVmax = 7.6 nM/min) but not by other ceramidases. RBM1-151 is applicable for basic biological studies of lipid amidase function, as well as potential diagnostic/prognostic evaluations of diseases involving dysregulated AC, NAAA, or FAAH (Farber disease, cancer) .
    RBM1-151
  • HY-16021
    AC-430

    		JAK Inflammation/Immunology
    AC-430 is a JAK2 inhibitor. AC-430 can be used in the research of rheumatoid arthritis .
    AC-430
  • HY-P11491
    Ac2-26 (mouse)

    		Formyl Peptide Receptor (FPR) Reactive Oxygen Species (ROS) Inflammation/Immunology
    Ac2-26 (mouse) is the N-terminal active peptide of Annexin A1 (AnxA1). Ac2-26 (mouse) regulates the inflammatory response by modulating the formyl peptide receptor (FPR) signaling pathway. Ac2-26 (mouse) can promote the release of chemokines and inhibit the production of ROS. Ac2-26 (mouse) can be used for the research of inflammation, such as rheumatoid arthritis .
    Ac2-26 (mouse)
  • HY-106025
    Radequinil

    AC-3933

    		 GABA Receptor Neurological Disease
    Radequinil (AC-3933) is a benzodiazepine receptor (BzR) partial inverse agonist. AC-3933 binds to GABA(-) and GABA(+) ligand with Kis of 5.15 and 6.11 nM, respectively .
    Radequinil
  • HY-P5525
    AC3-I, myristoylated

    Autocamtide-3 Derived Inhibitory Peptide

    		 CaMK Others
    AC3-I, myristoylated is a biological active peptide. (This is a myristoylated form of Autocamtide-3-Derived Inhibitory Peptide (AC3-I), a highly specific inhibitor of Calmodulin-Dependent Protein Kinase ll (CaMKII) that is resistant to proteolysis. AC3-I is derived from Autocamtide-3, a substrate for CaMKII, with the Thr-9 phosphorylation site substituted with Ala.)
    AC3-I, myristoylated
  • HY-178336
    AC-340

    		VD/VDR HDAC Microtubule/Tubulin Inflammation/Immunology Cancer
    AC-340 is a potent hybrid VDR agonist/HDAC inhibitor. AC-340 superinduces VDR target genes (e.g., CYP24A1) and inhibits HDAC6 (IC50 = 0.37 μM) with ~10-fold selectivity over HDAC2. AC-340 induces VDR hyperagonism by causing widespread protein hyperacetylation (e.g., tubulin and H3K9/K27), which leads to elevated H3K27 acetylation on VDR target genes. AC-340 can be used for melanoma cancer research .
    AC-340
  • HY-136940
    Ac22(Az8)2

    		BCRP Cancer
    Ac22(Az8)2​ is a selective BCRP inhibitor (EC50: 1-2 nM). Ac22(Az8)2 can restore the drug sensitivity of BCRP-overexpressing cells by inhibiting BCRP-ATPase activity, blocking drug efflux, and increasing intracellular drug accumulation. Ac22(Az8)2 can be used in the research of BCRP-mediated multidrug-resistant cancers .
    Ac22(Az8)2
  • HY-P2939
    Chondroitinase AC

    		Apoptosis Biochemical Assay Reagents Cancer
    Chondroitinase AC is a hydrolytic enzyme. Chondroitinase AC degrades chondroitin sulfate A and chondroitin sulfate C. Chondroitinase AC inhibits the invasion and proliferation of melanoma cells and endothelial cells, and increases apoptosis. Chondroitinase AC can be used in research on melanoma and other cancers .
    Chondroitinase AC
  • HY-154829A
    AC-099 hydrochloride

    		Neuropeptide FF Receptor Inflammation/Immunology
    AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 hydrochloride attenuates spinal nerve ligation-induced hypersensitivity in rats .
    AC-099 hydrochloride
  • HY-18234B
    Leupeptin Ac-LL

    		Ser/Thr Protease Metabolic Disease Inflammation/Immunology Cancer
    Leupeptin Ac-LL is a protease inhibitor from actinomycetes. Leupeptin Ac-LL has antiplasmin activity .
    Leupeptin Ac-LL
  • HY-P4449
    Ac-VRPR-AMC

    		Caspase Cancer
    Ac-VRPR-AMC is a fluorogenic metacaspase substrate. Ac-VRPR-AMC can be used to tests metacaspase activity .
    Ac-VRPR-AMC
  • HY-111554
    AcLys-PABC-VC-Aur0101

    		Microtubule/Tubulin Drug-Linker Conjugates for ADC Cancer
    AcLys-PABC-VC-Aur0101 is a agent-linker conjugate for ADC (anti-CXCR4 ADC) with potent antitumor activity by using Aur0101 (an auristatin microtubule inhibitor), linked via the cleavable linker AcLys-PABC-VC .
    AcLys-PABC-VC-Aur0101
  • HY-RS00167
    Acly Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Acly Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acly gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Acly Mouse Pre-designed siRNA Set A
    Acly Mouse Pre-designed siRNA Set A
  • HY-RS00168
    Acly Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Acly Rat Pre-designed siRNA Set A contains three designed siRNAs for Acly gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Acly Rat Pre-designed siRNA Set A
    Acly Rat Pre-designed siRNA Set A
  • HY-157235
    AC Antibody affinity resin

    		Biochemical Assay Reagents Inflammation/Immunology
    AC Antibody affinity resin is AC commonly used packing. AC Antibody affinity resin has highly cross-linked agarose matrix with 85 μm of average particle size. AC Antibody affinity resin has alkali-resistant protein A derivative (E. coli) ligand. AC Antibody affinity resin can be used for antibody affinity chromatography .
    AC Antibody affinity resin
  • HY-174151
    XSJ110

    		Topoisomerase Apoptosis Cancer
    XSJ110 is a potent irreversible topoisomerase I (Topo I) inhibitor with an IC50 value of 0.133 μM. XSJ110 blocks DNA topoisomerization, induces DNA double-strand breaks, and triggers cell cycle arrest at G0/G1 phase, inducing tumor cell apoptosis. XSJ110 is promising for research of ampullary carcinoma (AC) .
    XSJ110

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