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Obtusifolin 

Cat. No.: HY-N2098
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Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein.

For research use only. We do not sell to patients.

Obtusifolin Chemical Structure

Obtusifolin Chemical Structure

CAS No. : 477-85-0

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Description

Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway[1]. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein[2].

IC50 & Target

NF-κB

 

In Vitro

Obtusifolin (1, 10, 100 μM) inhibits MUC5AC gene expression induced by EGF, PMA, or TNF-α in NCI-H292 cells[1].

Molecular Weight

284.26

Formula

C₁₆H₁₂O₅

CAS No.

477-85-0

SMILES

O=C1C2=C(C=CC=C2O)C(C3=CC(C)=C(O)C(OC)=C13)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ObtusifolinNF-κBNuclear factor-κBNuclear factor-kappaBMUC5ACmucinairwayepithelialphthalateestersbreastcancerbonemetastasisInhibitorinhibitorinhibit

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