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Obtusifolin 

Cat. No.: HY-N2098 Purity: 99.80%
Handling Instructions

Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein.

For research use only. We do not sell to patients.

Obtusifolin Chemical Structure

Obtusifolin Chemical Structure

CAS No. : 477-85-0

Size Price Stock Quantity
5 mg USD 303 In-stock
Estimated Time of Arrival: December 31
10 mg USD 514 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway[1]. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein[2].

IC50 & Target[1]

NF-κB

 

In Vitro

Obtusifolin (1, 10, 100 μM) inhibits MUC5AC gene expression induced by EGF, PMA, or TNF-α in NCI-H292 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

284.26

Formula

C16H12O5

CAS No.
SMILES

O=C1C2=C(C=CC=C2O)C(C3=CC(C)=C(O)C(OC)=C13)=O

Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (35.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5179 mL 17.5895 mL 35.1791 mL
5 mM 0.7036 mL 3.5179 mL 7.0358 mL
10 mM 0.3518 mL 1.7590 mL 3.5179 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Obtusifolin
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HY-N2098
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