477-85-0
477-85-0
Chemical Structure
Obtusifolin
- CAS. Nr.: 477-85-0
- Formula:C16H12O5
- Molecular Weight:284.26
IUPAC Name: 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione
InChIKey: NYRXUBDGDSRBGB-UHFFFAOYSA-N
SMILES: O=C1C2=C(C=CC=C2O)C(C3=CC(C)=C(O)C(OC)=C13)=O
Biological Activity: Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway[1]. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein[2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Obtusifolin | 99.38% | Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein. | ||||||||||||||||||||
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Obtusifolin (Standard) | ≥98% | Obtusifolin (Standard) is the analytical standard of Obtusifolin. This product is intended for research and analytical applications. Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein. | ||||||||||||||||||||
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Digitolutein | 94.99% | Digitolutein is a natural product that can be isolated from the stem bark and the roots of Morinda lucida Benth. Digitolutein effectively inhibits the growth of Plasmodium falciparum with an IC50 value of 12.92 μg/mL. Digitolutein can be used for the research of infection. | ||||||||||||||||||||
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1,2,3,7-Tetrahydroxy-8-methoxy-6-methyl-9,10-anthraquinone | 1,2,3,7-Tetrahydroxy-8-methoxy-6-methyl-9,10-anthraquinone is an anthraquinone compound isolated from the seeds of Cassia obtusifolia. | |||||||||||||||||||||
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7-Methoxy obtusifolin | 7-Methoxy obtusifolin (Compound 4) is a competitive tyrosinase inhibitor with an IC50 of 7.0 μM. | |||||||||||||||||||||
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OAT1/3-IN-1 | OAT1/3-IN-1 (compound 7) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-1 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-1 can be used to study mercury-induced kidney damage. | |||||||||||||||||||||
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OAT1/3-IN-2 | OAT1/3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-2 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-2 can be used to study mercury-induced kidney damage. | |||||||||||||||||||||
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1,3,8-Trihydroxy-2-methoxyanthraquinone | 1,3,8-Trihydroxy-2-methoxyanthraquinone is an anthraquinone found in the roots of Morinda officinalis How. 1,3,8-Trihydroxy-2-methoxyanthraquinoneand inhibits LPS (HY-D1056)-stimulated nitric oxide production. | |||||||||||||||||||||
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3,8-Dihydroxy-1,2-dimethoxyanthraquinone | 3,8-Dihydroxy-1,2-dimethoxyanthraquinone is an anthraquinone found in the roots of Morinda officinalis How. 3,8-Dihydroxy-1,2-dimethoxyanthraquinone does not inhibit LPS (HY-D1056)-stimulated NO production with an IC50 >50 μM. | |||||||||||||||||||||
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2,8-Dihydroxy-1-methoxyanthracene-9,10-dione | 2,8-Dihydroxy-1-methoxyanthracene-9,10-dione is an anthraquinone that can be found in the roots of Morinda officinalis How. | |||||||||||||||||||||
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2-Hydroxyl emodin-1-methyl ether | 98.87% | 2-Hydroxyl emodin-1-methyl ether (Compound 5) is an anthraquinone that can be isolated from the seeds of Cassia obtusifolia. | ||||||||||||||||||||
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5-Hydroxyalizarin 1-methyl ether | 5-Hydroxyalizarin 1-methyl ether is a quinone compound isolated from Hymenodictyon excelsum. | |||||||||||||||||||||
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References
- [1]. Choi BS, et al. Obtusifolin isolated from the seeds of Cassia obtusifolia regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via affecting NF-κB pathway. Phytother Res. 2019 Apr;33(4):919-928. [Content Brief]
- [2]. Hsu YL, et al. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein. J Agric Food Chem. 2014 Dec 10;62(49):11933-40. [Content Brief]
