Anabsinthin
Anabsinthin is a dimeric sesquiterpene lactone. Anabsinthin can be found in Artemisia absinthium L. (wormwood). Anabsinthin modulates intracellular calcium levels, mediates anti-inflammatory and antioxidant effects. Anabsinthin inhibits Phorbol 12-myristate 13-acetate (HY-18739)-induced superoxide anion production, increased iNOS and MUC5AC protein expression, and IL-1β transcription upregulation. Anabsinthin can be used for the research of citrus canker.
For research use only. We do not sell to patients.
- CAS No.: 6903-12-4
- Formula: C30H40O6
- Molecular Weight:496.64
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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iNOS |
Anabsinthin (1 mM) increases cytosolic calcium levels in BEAS-2B cells, and this activity is not mediated by hTAS2R46[1].
Anabsinthin (1, 10 μM; 1 h) inhibits PMA-induced superoxide anion production in BEAS-2B cells, and this activity is mediated by hTAS2R46[1].
Anabsinthin (1, 10 μM; 18 h) inhibits PMA-induced iNOS protein expression (but not mRNA expression), MUC5AC protein expression, and IL-1β mRNA expression in BEAS-2B cells, with the inhibitory activity on IL-1β mRNA expression not mediated by hTAS2R46.[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human bronchial epithelial BEAS-2B cells
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Concentration:1, 10 μM
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Incubation Time:18 h
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Result:Significantly prevented PMA-induced up-regulation of IL-1β transcription.
Did not show reverted inhibitory effect when co-treated with 1 μM of the hTAS2R46 antagonist 3β-hydroxydihydrocostunolide.
Chemical Information
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CAS No. 6903-12-4
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Molecular Weight 496.64
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Formula C30H40O6
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SMILES
C[C@@]12[C@]34C([C@@](O2)(CC[C@]5([H])[C@]4([H])OC([C@H]5C)=O)C)([H])[C@@](C1)([H])[C@@]6([H])[C@]3([H])C(C)=C7[C@]6([H])[C@@](O)(CC[C@]8([H])[C@]7([H])OC([C@H]8C)=O)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Talmon M, et al. Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells. J Nat Prod. 2020 Jun 4;83 (6):1740-1750. [Content Brief]
[2]. Aberham A, et al. Analysis of sesquiterpene lactones, lignans, and flavonoids in wormwood (Artemisia absinthium L.) using high-performance liquid chromatography (HPLC)-mass spectrometry, reversed phase HPLC, and HPLC-solid phase extraction-nuclear magnetic resonance. J Agric Food Chem. 2010;58(20):10817-10823. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anabsinthin Related Classifications
HY-N18053 Related Classifications
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