2. Others Anti-infection NF-κB Immunology/Inflammation
  3. Drug Derivative Bacterial NF-κB NO Synthase
  4. Anabsinthin

Anabsinthin is a dimeric sesquiterpene lactone. Anabsinthin can be found in Artemisia absinthium L. (wormwood). Anabsinthin modulates intracellular calcium levels, mediates anti-inflammatory and antioxidant effects. Anabsinthin inhibits Phorbol 12-myristate 13-acetate (HY-18739)-induced superoxide anion production, increased iNOS and MUC5AC protein expression, and IL-1β transcription upregulation. Anabsinthin can be used for the research of citrus canker.

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Anabsinthin

Anabsinthin Chemical Structure

CAS No. : 6903-12-4

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Anabsinthin Related Antibodies

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Description

Anabsinthin is a dimeric sesquiterpene lactone. Anabsinthin can be found in Artemisia absinthium L. (wormwood). Anabsinthin modulates intracellular calcium levels, mediates anti-inflammatory and antioxidant effects. Anabsinthin inhibits Phorbol 12-myristate 13-acetate (HY-18739)-induced superoxide anion production, increased iNOS and MUC5AC protein expression, and IL-1β transcription upregulation. Anabsinthin can be used for the research of citrus canker[1][2][3].

IC50 & Target[1]

iNOS

 

In Vitro

Anabsinthin (1 mM) increases cytosolic calcium levels in BEAS-2B cells, and this activity is not mediated by hTAS2R46[1].
Anabsinthin (1, 10 μM; 1 h) inhibits PMA-induced superoxide anion production in BEAS-2B cells, and this activity is mediated by hTAS2R46[1].
Anabsinthin (1, 10 μM; 18 h) inhibits PMA-induced iNOS protein expression (but not mRNA expression), MUC5AC protein expression, and IL-1β mRNA expression in BEAS-2B cells, with the inhibitory activity on IL-1β mRNA expression not mediated by hTAS2R46.[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anabsinthin Related Antibodies

Real Time qPCR[1]

Cell Line: human bronchial epithelial BEAS-2B cells
Concentration: 1, 10 μM
Incubation Time: 18 h
Result: Significantly prevented PMA-induced up-regulation of IL-1β transcription.
Did not show reverted inhibitory effect when co-treated with 1 μM of the hTAS2R46 antagonist 3β-hydroxydihydrocostunolide.
Molecular Weight

496.64

Formula

C30H40O6
CAS No.
SMILES

C[C@@]12[C@]34C([C@@](O2)(CC[C@]5([H])[C@]4([H])OC([C@H]5C)=O)C)([H])[C@@](C1)([H])[C@@]6([H])[C@]3([H])C(C)=C7[C@]6([H])[C@@](O)(CC[C@]8([H])[C@]7([H])OC([C@H]8C)=O)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anabsinthin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anabsinthin6903-12-4Drug DerivativeBacterialNF-κBNO SynthaseDrug derivativeNuclear factor-κBNuclear factor-kappaBNitric oxide synthasesNOSCPBPIL-1βhTAS2R46PBPBEAS-2B cellsiNOScitrus cankerXanthomonas citriArtemisia absinthiumMUC5ACInhibitorinhibitorinhibit

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