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Itaconate-alkyne (Synonyms: ITalk)

Cat. No.: HY-133870
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Itaconate-alkyne (ITalk) is a specific bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of Itaconation in living cells. Itaconate-alkyne, a functional analogue of Itaconate, exhibits comparable antiinflammatory effect with Itaconate and enables the labeling of bona fide targets of Itaconate.

For research use only. We do not sell to patients.

Itaconate-alkyne Chemical Structure

Itaconate-alkyne Chemical Structure

CAS No. : 2454181-83-8

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Description

Itaconate-alkyne (ITalk) is a specific bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of Itaconation in living cells. Itaconate-alkyne, a functional analogue of Itaconate, exhibits comparable antiinflammatory effect with Itaconate and enables the labeling of bona fide targets of Itaconate[1].

In Vitro

Itaconate-alkyne (ITalk; 0.005, 0.01, 0.05, 0.1, 0.5, 1, 5, 10 mM; 0-4 hours) has the concentration- and time-dependent labeling in the lysates of Raw264.7 cells[1].
Itaconate-alkyne (100 μM; for 4 hours) significantly increases the protein level of NRF-2 in LPS (100 ng/mL)-stimulated Raw264.7 cells and significantly inhibits lactate production in LPS-stimulated Raw264.7 cells. Itaconate-alkyne significantly inhibits the secretion of interlukin-1β (IL-1β) in LPS-timulated Raw264.7 cells[1].
Itaconate-alkyne (100 μM; for 12 hours) does not affect the cell viability of Raw264.7 cells[1].
Itaconate-alkyne can capture itaconate targets including DNA damage-binding protein 1 (DDB1), Gelsolin (GSN), ATP-citrate synthase (ACLY) and Adenylate kinase 2 (AK2) in inflammatory macrophages[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

238.28

Formula

C₁₃H₁₈O₄

CAS No.

2454181-83-8

SMILES

O=C(O)C(CC(OCCCCCCC#C)=O)=C

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Itaconate-alkyneITalkOthersbioorthogonalprobequantitativesite-specificchemoproteomicItaconationItaconateantiinflammatorylabelingRaw264.7NRF-2LPSIL-1βDDB1GSNACLYAK2Inhibitorinhibitorinhibit

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Itaconate-alkyne
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HY-133870
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