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AC-green (Synonyms: VDP-green)

Cat. No.: HY-D1258
Handling Instructions

AC-green (VDP-green) is a β-allyl carbamate fluorescent probe for specifically imaging vicinal dithiol proteins (VDPs) in living systems (λexem=400/475 nm). AC-green can detect the reduced bovine serum albumin (rBSA) with high sensitivity. AC-green displays low toxicity and features high sensitivity, and is suitable for sensing VDPs in living cells and zebrafishes.

For research use only. We do not sell to patients.

AC-green Chemical Structure

AC-green Chemical Structure

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Description

AC-green (VDP-green) is a β-allyl carbamate fluorescent probe for specifically imaging vicinal dithiol proteins (VDPs) in living systems (λexem=400/475 nm). AC-green can detect the reduced bovine serum albumin (rBSA) with high sensitivity. AC-green displays low toxicity and features high sensitivity, and is suitable for sensing VDPs in living cells and zebrafishes[1].

In Vitro

AC-green (VDP-green) can respond to VDPs with more than 60-fold increase of emission in aqueous solution, while there is no significant interference from biological thiols, amino acids or inorganic salts[1].
AC-green (2 μM; 90 min) has no apparent fluorescence signal within the pH range of 5.0-9.0. Addition of rBSA turns on the fluorescence[1].
AC-gree (10 μM) has low cytotoxicity in HepG2 cells and Hela cells[1].
AC-gree (10 μM; for 15 min) images VDPs in living HepG2 cells and bright green fluorescence appeared. This fluorescence is inhibited when the cells are pretreated with PAO, a popular specificligand for protein vicinal dithiols[1].
AC-gree (10 μM; for 20 min) incubates with zebrafishes has a strong fluorescence signal appeared in the green channel[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

435.47

Formula

C₂₄H₂₅N₃O₅

SMILES

O=C(NC1=CC2=CC=C(C=C2OC1=O)N(CC)CC)C(COC(NC3=CC=CC=C3)=O)=C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AC-greenVDP-greenOthersβ-allyl carbamatevicinaldithiolproteinsVDPsbovineserumalbuminrBSAHepG2HelaInhibitorinhibitorinhibit

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AC-green
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HY-D1258
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