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Cat. No.: HY-181058

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Cyclopamine-COO-2-ethoxy-1,3-benzodioxole-O-C-Triazole-C5-AC

Cyclopamine-COO-2-ethoxy-1,3-benzodioxole-O-C-Triazole-C5-AC is a drug-linker conjugate, with Cyclopamine (HY-17024) as its drug moiety. Cyclopamine-COO-2-ethoxy-1,3-benzodioxole-O-C-Triazole-C5-AC itself exhibits no significant anti-tumor activity. Cyclopamine-COO-2-ethoxy-1,3-benzodioxole-O-C-Triazole-C5-AC can be used for the synthesis of ADC molecules.

For research use only. We do not sell to patients.

Formula: C₄₇H₆₄N₄O₁₀
Molecular Weight:845.03

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Cyclopamine-COO-2-ethoxy-1,3-benzodioxole-O-C-Triazole-C5-AC Chemical Structure

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Drug-Linker Conjugates for ADC Isoforms :

In Vitro

Cyclopamine-COO-2-ethoxy-1,3-benzodioxole-O-C-Triazole-C5-AC (Compound 9) (100-200 μg/mL; 72 h) shows no significant antiproliferative activity against A375 and SK-MEL-5 melanoma cells (with IC₅₀ values of 10.96 μM and 10.40 μM, respectively), and does not affect cell apoptosis or the EGFR signaling pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 845.03
Formula C₄₇H₆₄N₄O₁₀
SMILES

CC1=C2[C@@]([C@@]3([H])[C@]([C@@]4(C(C[C@@H](O)CC4)=CC3)C)([H])C2)([H])CC[C@@]15[C@@H]([C@@]6([H])[C@](C[C@H](C)CN6C(OCC7=CC(OCC8=CN(CCCCCC(O)=O)N=N8)=C9C(OC(OCC)O9)=C7)=O)([H])O5)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ricciardella G, et al. Natural products as payloads for antibody-drug conjugates: Cyclopamine linked to cetuximab for hedgehog pathway inhibition. Bioorg Chem. 2026;169:109452. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

Cyclopamine-COO-2-ethoxy-1,3-benzodioxole-O-C-Triazole-C5-AC

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Biological Activity
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Cyclopamine-COO-2-ethoxy-1,3-benzodioxole-O-C-Triazole-C5-AC

All Drug-Linker Conjugates for ADC Isoforms

Biological Activity

Description

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Cyclopamine-COO-2-ethoxy-1,3-benzodioxole-O-C-Triazole-C5-AC Related Classifications

HY-181058 Related Classifications

Bioz

Keywords

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