Cyclopamine-COO-2-ethoxy-1,3-benzodioxole-O-C-Triazole-C5-AC 

Cyclopamine-COO-2-ethoxy-1,3-benzodioxole-O-C-Triazole-C5-AC is a drug-linker conjugate, with Cyclopamine (HY-17024) as its drug moiety. Cyclopamine-COO-2-ethoxy-1,3-benzodioxole-O-C-Triazole-C5-AC itself exhibits no significant anti-tumor activity. Cyclopamine-COO-2-ethoxy-1,3-benzodioxole-O-C-Triazole-C5-AC can be used for the synthesis of ADC molecules^[1].

Cyclopamine-COO-2-ethoxy-1,3-benzodioxole-O-C-Triazole-C5-AC (Compound 9) (100-200 μg/mL; 72 h) shows no significant antiproliferative activity against A375 and SK-MEL-5 melanoma cells (with IC₅₀ values of 10.96 μM and 10.40 μM, respectively), and does not affect cell apoptosis or the EGFR signaling pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

845.03

C₄₇H₆₄N₄O₁₀

CC1=C2[C@@]([C@@]3([H])[C@]([C@@]4(C(C[C@@H](O)CC4)=CC3)C)([H])C2)([H])CC[C@@]15[C@@H]([C@@]6([H])[C@](C[C@H](C)CN6C(OCC7=CC(OCC8=CN(CCCCCC(O)=O)N=N8)=C9C(OC(OCC)O9)=C7)=O)([H])O5)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ricciardella G, et al. Natural products as payloads for antibody-drug conjugates: Cyclopamine linked to cetuximab for hedgehog pathway inhibition. Bioorg Chem. 2026;169:109452.  [Content Brief]