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  2. Dentonin

Dentonin (Synonyms: AC-100)

Cat. No.: HY-P2633
Handling Instructions

Dentonin (AC-100) is a synthetic fragment derived from MEPE. Dentonin enhances osteogenesis by promoting osteoprogenitor adhesion and facilitates immature adherent cells survival. Dentonin has no significant effect to mature osteoblasts. Dentonin can be used for the research of phosphate homeostasis and bone metabolism.

For research use only. We do not sell to patients.

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Dentonin Chemical Structure

Dentonin Chemical Structure

CAS No. : 400090-20-2

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Description

Dentonin (AC-100) is a synthetic fragment derived from MEPE. Dentonin enhances osteogenesis by promoting osteoprogenitor adhesion and facilitates immature adherent cells survival. Dentonin has no significant effect to mature osteoblasts. Dentonin can be used for the research of phosphate homeostasis and bone metabolism[1].

In Vitro

MEPE is a a member of the SIBLING (Small Integrin-Binding Ligand, N-linked Glycoprotein) family of secreted glycophosphoproteins.  MEPE  regulates bone mass and influence osteoblast activity.[1].
Dentonin (3-30 μg/ml; 2-24 hours) significantly increases the numbers of cell and shows enhanced promotion of cell adhesion. However, it has no significant differences in terms of numbers of cells adhered[2].
Dentonin (3-30 μg/ml; 2-24 hours) enhances osteoblast spreading, it exhibits significantly increased cell areas compared to all other treatment[2].

Molecular Weight

2538.59

Formula

C₁₀₇H₁₆₀N₃₀O₄₂

CAS No.

400090-20-2

Sequence Shortening

TDLQERGDNDISPFSGDGQPFKD

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DentoninAC-100AC100AC 100OthersOsteogenesis Inducercell adhesionosteoblastfocal complex formationInhibitorinhibitorinhibit

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