Glucocerebrosidase-IN-2
Glucocerebrosidase-IN-2 (compound 12) is a quinazoline analogue and an inhibitor of glucocerebrosidase (GC). Glucocerebrosidase-IN-2 has the potential to improve GC translocation to lysosomes in Gaucher disease patient-derived cells (mostly carrying the N370S mutation). Glucocerebrosidase-IN-2 inhibits the hydrolysis of 4-methylumbelliferone β-D-glucopyranoside (4MU) and fluorescent glycosylceramide (FlourGC) in N370S mutant tissues with an AC50 of 25.29 μM.
For research use only. We do not sell to patients.
- CAS No.: 851185-20-1
- Formula: C25H23N5O4S
- Molecular Weight:489.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 851185-20-1
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Molecular Weight 489.55
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Formula C25H23N5O4S
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SMILES
O=S(C1=CC=C2OCCOC2=C1)(N3CCN(C4=NC(C5=CN=CC=C5)=NC6=C4C=CC=C6)CC3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glucocerebrosidase-IN-2 Related Classifications
HY-156020 Related Classifications
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