1. Metabolic Enzyme/Protease
  2. Glucosidase
  3. ML198

ML198 

Cat. No.: HY-117861 Purity: ≥98.0%
Handling Instructions

ML198 is a glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM. ML198 is an activator and non-inhibitory chaperone of glucocerebrosidase. ML198 can be used for the research of Gaucher disease.

For research use only. We do not sell to patients.

ML198 Chemical Structure

ML198 Chemical Structure

CAS No. : 1380716-06-2

Size Price Stock Quantity
5 mg USD 200 In-stock
Estimated Time of Arrival: December 31
10 mg USD 320 In-stock
Estimated Time of Arrival: December 31
25 mg USD 640 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1020 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
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500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

ML198 is a glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM. ML198 is an activator and non-inhibitory chaperone of glucocerebrosidase. ML198 can be used for the research of Gaucher disease[1].

IC50 & Target

EC50: 0.4 μM (glucocerebrosidase)[1]

In Vitro

ML198 is stable in D-PBS pH 7.4 at room temperature over 48 hr[1].
ML198 increases translocation of GCase to the lysosome (20% cell translocation at 5 µM, compared to 5% of DMSO) in human fibroblasts[1].
ML198 shows promising microsomal stability and Caco-2 permeability, with low water solubility[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

290.32

Formula

C17H14N4O

CAS No.
SMILES

O=C(NC1=CC=C(C=C1)C#C)C2=C3N=C(C=C(N3N=C2)C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (17.22 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4445 mL 17.2224 mL 34.4447 mL
5 mM 0.6889 mL 3.4445 mL 6.8889 mL
10 mM 0.3444 mL 1.7222 mL 3.4445 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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ML198
Cat. No.:
HY-117861
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