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Cat. No.: HY-171489

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Mal-VC-PAB-EDA-N-Ac-Calicheamicin

Mal-VC-PAB-EDA-N-Ac-Calicheamicin is a Drug-Linker Conjugate for ADC with potent antitumor activity. Mal-VC-PAB-EDA-N-Ac-Calicheamicin consists of ADC toxin Calicheamicin (HY-19609) and a linker. Mal-VC-PAB-EDA-N-Ac-Calicheamicin can be used for synthesis of ADC, PF-06647263 (HY-111965).

For research use only. We do not sell to patients.

CAS No.: 2028299-61-6
Formula: C₉₃H₁₂₈IN₁₁O₃₁S₃
Molecular Weight:2119.17

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Mal-VC-PAB-EDA-N-Ac-Calicheamicin Chemical Structure

CAS No.: 2028299-61-6

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Use of MCE Products

One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Traditional Cytotoxic Agents

All Drug-Linker Conjugates for ADC Isoforms :

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2028299-61-6
Molecular Weight 2119.17
Formula C₉₃H₁₂₈IN₁₁O₃₁S₃
SMILES

C[C@H]1O[C@H](C[C@@H]([C@@H]1SC(C(C(C)=C(C(O[C@@H]2O[C@H]([C@@H]([C@H]([C@H]2O)OC)O)C)=C3OC)I)=C3OC)=O)O)ON[C@@H]4[C@@H](C)OC(O[C@@H](C#C/C=C\C#C[C@@]/5(O)CC6=O)C(C5=C/CSSC(C)(CCC(NCCNC(OCC7=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN8C(C=CC8=O)=O)=O)=O)=O)C=C7)=O)=O)C)=C6NC(OC)=O)[C@H](O[C@H]9C[C@H](OC)[C@@H](N(C(C)=O)CC)CO9)[C@H]4O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Garrido-Laguna I, et al. First-in-human, phase I study of PF-06647263, an anti-EFNA4 calicheamicin antibody-drug conjugate, in patients with advanced solid tumors. Int J Cancer. 2019 Oct 1;145(7):1798-1808. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Mal-VC-PAB-EDA-N-Ac-Calicheamicin

All Drug-Linker Conjugates for ADC Isoforms