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AC 187 

Cat. No.: HY-P1393
Handling Instructions

AC 187 is a potent and orally active amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187 shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 has neuroprotective effects.

For research use only. We do not sell to patients.

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AC 187 Chemical Structure

AC 187 Chemical Structure

CAS No. : 151804-77-2

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Description

AC 187 is a potent and orally active amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187 shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 has neuroprotective effects[1][2].

IC50 & Target

IC50: 0.48 nM (amylin receptor)

In Vitro

AC 187 blocks amyloidβ protein (Aβ)-induced neurotoxicity. Treatment of cultures with AC 187 before exposure to Aβ results in significantly improved neuronal survival[1].
AC187 attenuates the activation of initiator and effector caspases that mediate Aβ-induced apoptotic cell death[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AC 187 (30 mg/mL) increases glucagon concentration, accelerates gastric emptying of liquids, and results in an exaggerated post-challenge glycemia in hyperinsulinemic clamps in Sprague-Dawley (HSD) rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2890.25

Formula

C127H205N37O40

CAS No.
Sequence

Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2

Sequence Shortening

Ac-VLGKLSQELHKLQTYPRTNTGSNTY-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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AC 187
Cat. No.:
HY-P1393
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