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AC 187 

Cat. No.: HY-P1393
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AC 187 is an orally active, potent amylin receptor antagonist (IC50= 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. AC 187 blocks amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. AC 187 increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo.

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AC 187 Chemical Structure

AC 187 Chemical Structure

CAS No. : 151804-77-2

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Description

AC 187 is an orally active, potent amylin receptor antagonist (IC50= 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. AC 187 blocks amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. AC 187 increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo.

Molecular Weight

2890.25

Formula

C₁₂₇H₂₀₅N₃₇O₄₀

CAS No.

151804-77-2

Sequence

Ac-{Val}{Leu}{Gly}{Lys}{Leu}{Ser}{Gln}{Glu}{Leu}{His}{Lys}{Leu}{Gln}{Thr}{Tyr}{Pro}{Arg}{Thr}{Asn}{Thr}{Gly}{Ser}{Asn}{Thr}{Tyr}-NH2

Sequence Shortening

Ac-VLGKLSQELHKLQTYPRTNTGSNTY-NH2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AC 187AC187AC-187OthersInhibitorinhibitorinhibit

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AC 187
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HY-P1393
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