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Cat. No.: HY-P11779

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Ac-RKAA-PABC-MMAE

Ac-RKAA-PABC-MMAE is a Drug-Linker Conjugates for ADC. Ac-RKAA-PABC-MMAE consists of the ADC Cytotoxin MMAE (HY-15162) and a linker. Ac-RKAA-PABC-MMAE can be used for synthesis of ADCs.

For research use only. We do not sell to patients.

CAS No.: 2768774-89-4
Formula: C₆₇H₁₁₀N₁₄O₁₄
Molecular Weight:1335.70

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

Ac-RKAA-PABC-MMAE Chemical Structure

CAS No.: 2768774-89-4

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Biological Activity
- Description
- In Vitro
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Biological Activity

Description

Ac-RKAA-PABC-MMAE is a Drug-Linker Conjugates for ADC. Ac-RKAA-PABC-MMAE consists of the ADC Cytotoxin MMAE (HY-15162) and a linker. Ac-RKAA-PABC-MMAE can be used for synthesis of ADCs^[1].

All Drug-Linker Conjugates for ADC Isoforms :

In Vitro

Ac-RKAA-PABC-MMAE can be used to synthesize anti-CD79b-RKAA-MMAE ADC for cancer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2768774-89-4
Molecular Weight 1335.70
Formula C₆₇H₁₁₀N₁₄O₁₄
Sequence

Ac-Arg-Lys-Ala-Ala-{PABC-MMAE}
Sequence Shortening

Ac-RKAA-{PABC-MMAE}
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Probst P, et al. Broadening the Therapeutic Window of ADCs Using Site-Specific Bioconjugation Showcased by an MMAE-Containing Peptide Linker in a CD79b-Targeting ADC. Mol Cancer Ther. 2025;24(6):803-815. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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Ac-RKAA-PABC-MMAE

All Drug-Linker Conjugates for ADC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Ac-RKAA-PABC-MMAE Related Classifications

HY-P11779 Related Classifications