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  4. Ac-RHKK(Ac)-AMC

Ac-RHKK(Ac)-AMC (Compound S1) is a fluorescent substrate for SITR6, that is based on p53 sequence. Ac-RHKK(Ac)-AMC mimics H3K56 deacetylation site and significantly increases the deacetylation signal with low signal-to-background ratio. Ac-RHKK(Ac)-AMC can be used for ageing and cancers research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Ac-RHKK(Ac)-AMC

Ac-RHKK(Ac)-AMC Chemical Structure

CAS No. : 1193634-36-4

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Based on 1 publication(s) in Google Scholar

Ac-RHKK(Ac)-AMC Related Antibodies

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Description

Ac-RHKK(Ac)-AMC (Compound S1) is a fluorescent substrate for SITR6, that is based on p53 sequence. Ac-RHKK(Ac)-AMC mimics H3K56 deacetylation site and significantly increases the deacetylation signal with low signal-to-background ratio. Ac-RHKK(Ac)-AMC can be used for ageing and cancers research[1].

Molecular Weight

808.93

Formula

C38H56N12O8
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ac-Arg-His-Lys-Lys(Ac)-AMC
Sequence Shortening

Ac-RHKK(Ac)-AMC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (123.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2362 mL 6.1810 mL 12.3620 mL
5 mM 0.2472 mL 1.2362 mL 2.4724 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2362 mL 6.1810 mL 12.3620 mL 30.9050 mL
5 mM 0.2472 mL 1.2362 mL 2.4724 mL 6.1810 mL
10 mM 0.1236 mL 0.6181 mL 1.2362 mL 3.0905 mL
15 mM 0.0824 mL 0.4121 mL 0.8241 mL 2.0603 mL
20 mM 0.0618 mL 0.3091 mL 0.6181 mL 1.5453 mL
25 mM 0.0494 mL 0.2472 mL 0.4945 mL 1.2362 mL
30 mM 0.0412 mL 0.2060 mL 0.4121 mL 1.0302 mL
40 mM 0.0309 mL 0.1545 mL 0.3091 mL 0.7726 mL
50 mM 0.0247 mL 0.1236 mL 0.2472 mL 0.6181 mL
60 mM 0.0206 mL 0.1030 mL 0.2060 mL 0.5151 mL
80 mM 0.0155 mL 0.0773 mL 0.1545 mL 0.3863 mL
100 mM 0.0124 mL 0.0618 mL 0.1236 mL 0.3091 mL
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Ac-RHKK(Ac)-AMC Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac-RHKK(Ac)-AMC1193634-36-4Fluorescent DyeFluorescent substrateSITR6p53 sequenceH3K56 deacetylationAgeingCancersInhibitorinhibitorinhibit

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