2. Apoptosis
  3. Apoptosis IAP
  4. Apoptosis inducer 61

Apoptosis inducer 61 (Compound 4E) is an Apoptosis inducer. Apoptosis inducer 61 significantly downregulates the expression of BIRC3 and activates Apoptosis. Anticancer agent 313 exhibits anticancer activity against ER+ breast cancer cells, triple-negative breast cancer cells, and gastric cancer cells.

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Apoptosis inducer 61

Apoptosis inducer 61 Chemical Structure

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Apoptosis inducer 61 Related Antibodies

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Description

Apoptosis inducer 61 (Compound 4E) is an Apoptosis inducer. Apoptosis inducer 61 significantly downregulates the expression of BIRC3 and activates Apoptosis. Anticancer agent 313 exhibits anticancer activity against ER+ breast cancer cells, triple-negative breast cancer cells, and gastric cancer cells[1].

IC50 & Target[1]

BIRC3

 

In Vitro

Apoptosis inducer 61 (1.56-200 μM; 48 h) potently inhibits the viability of MCF-7, MDA-MB-231 and HGC-27 cancer cells, with IC50 values of 5.61 μM, 8.18 μM and 5.68 μM, respectively; this compound exhibits selective toxicity toward cancer cells compared to non-malignant CCD-1072Sk cells[1].
Apoptosis inducer 61 (5.61 μM (MCF-7), 8.18 μM (MDA-MB-231); 48 h) induces apoptosis in MCF-7 and MDA-MB-231 breast cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 61 Related Antibodies

Apoptosis Analysis[1]

Cell Line: MCF-7 breast cancer cells, MDA-MB-231 breast cancer cells
Concentration: 5.61 μM (MCF-7); 8.18 μM (MDA-MB-231)
Incubation Time: 48 h
Result: Showed 12.35% apoptotic cells (8.73% early, 3.62% late) and 1.71% necrotic cells in MCF-7 cells.
Showed 9.78% apoptotic cells (5.54% early, 4.24% late) and 0.38% necrotic cells in MDA-MB-231 cells.
Molecular Weight

321.31

Formula

C16H12FN7
SMILES

FC1=CC=C(C=C1)C2=CN(N=N2)CC3=NN(C=C3)C4=NC=NC=C4
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Apoptosis inducer 61 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 61Apoptosis inducer61Apoptosis inducer-61ApoptosisIAPMPN domaingastric cancerPFKLACLYBIRC3breast cancerMCF-7ACSL4G6PDJAB1/CSN5Inhibitorinhibitorinhibit

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