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Cat. No.: HY-182002

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Apoptosis inducer 61

Apoptosis inducer 61 (Compound 4E) is an Apoptosis inducer. Apoptosis inducer 61 significantly downregulates the expression of BIRC3 and activates Apoptosis. Anticancer agent 313 exhibits anticancer activity against ER⁺ breast cancer cells, triple-negative breast cancer cells, and gastric cancer cells.

For research use only. We do not sell to patients.

Formula: C₁₆H₁₂FN₇
Molecular Weight:321.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Apoptosis inducer 61 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

BIRC3

All IAP Isoforms :

In Vitro

Apoptosis inducer 61 (1.56-200 μM; 48 h) potently inhibits the viability of MCF-7, MDA-MB-231 and HGC-27 cancer cells, with IC₅₀ values of 5.61 μM, 8.18 μM and 5.68 μM, respectively; this compound exhibits selective toxicity toward cancer cells compared to non-malignant CCD-1072Sk cells^[1].
Apoptosis inducer 61 (5.61 μM (MCF-7), 8.18 μM (MDA-MB-231); 48 h) induces apoptosis in MCF-7 and MDA-MB-231 breast cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

MCF-7 breast cancer cells, MDA-MB-231 breast cancer cells
Concentration:

5.61 μM (MCF-7); 8.18 μM (MDA-MB-231)
Incubation Time:

48 h
Result:

Showed 12.35% apoptotic cells (8.73% early, 3.62% late) and 1.71% necrotic cells in MCF-7 cells.
Showed 9.78% apoptotic cells (5.54% early, 4.24% late) and 0.38% necrotic cells in MDA-MB-231 cells.

Chemical Information

Molecular Weight 321.31
Formula C₁₆H₁₂FN₇
SMILES

FC1=CC=C(C=C1)C2=CN(N=N2)CC3=NN(C=C3)C4=NC=NC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Halac FA, et al. Triazole-substituted pyrazole-pyrimidine hybrids as anticancer agents: synthesis, cytotoxicity, apoptosis mechanisms, and JAB1-targeted structure-based design. Bioorg Chem. 2026;173:109633. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Apoptosis inducer 61

All IAP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Apoptosis inducer 61 Related Classifications

HY-182002 Related Classifications