AC-42 hydrochloride
Based on 1 Customer Validation
AC-42 hydrochloride is the hydrochloride salt form of AC-42 (HY-118806). AC-42 hydrochloride is an allosteric agonist for muscarinic M1 receptor with EC50s of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively. AC-42 hydrochloride stimulates the inositol phosphate (IP)-accumulation and calcium mobilization in CHO cells.
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- Reinheit : 98.42%
- CAS. Nr.: 447407-36-5
- Formel: C20H32ClNO
- Molecular Weight:337.93
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
0.21 μM
Compound: AC-42
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Partial agonist activity at EGFP-fused human full length M1 receptor expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
Partial agonist activity at EGFP-fused human full length M1 receptor expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
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[PMID: 22329602] |
| HEK293 | EC50 |
0.45 μM
Compound: AC-42
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Partial agonist activity at EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
Partial agonist activity at EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
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[PMID: 22329602] |
| HEK293 | EC50 |
0.72 μM
Compound: AC-42
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Partial agonist activity at EGFP-fused human M1 receptor N-terminal truncated at 11 residues expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
Partial agonist activity at EGFP-fused human M1 receptor N-terminal truncated at 11 residues expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
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[PMID: 22329602] |
| HEK293 | EC50 |
0.74 μM
Compound: AC-42
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Partial agonist activity at human full length M1 receptor expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
Partial agonist activity at human full length M1 receptor expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
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[PMID: 22329602] |
Chemical Information
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CAS. Nr. 447407-36-5
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Appearance Solid
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Molecular Weight 337.93
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Formel C20H32ClNO
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Color Off-white to light brown
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SMILES
O=C(C1=CC=CC=C1C)CCCN2CCC(CCCC)CC2.[H]Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 50 mg/mL (147.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Marlene A Jacobson, et al. The M1 muscarinic receptor allosteric agonists AC-42 and 1-[1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from the acetylcholine orthosteric site. Mol Pharmacol. 2010 Oct;78(4):648-57. [Content Brief]
[2]. Langmead CJ, et al., Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M(1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist. Mol Pharmacol. 2006 Jan;69(1):236-46. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9592 mL | 14.7960 mL | 29.5919 mL | 73.9798 mL |
| 5 mM | 0.5918 mL | 2.9592 mL | 5.9184 mL | 14.7960 mL | |
| 10 mM | 0.2959 mL | 1.4796 mL | 2.9592 mL | 7.3980 mL | |
| 15 mM | 0.1973 mL | 0.9864 mL | 1.9728 mL | 4.9320 mL | |
| 20 mM | 0.1480 mL | 0.7398 mL | 1.4796 mL | 3.6990 mL | |
| 25 mM | 0.1184 mL | 0.5918 mL | 1.1837 mL | 2.9592 mL | |
| 30 mM | 0.0986 mL | 0.4932 mL | 0.9864 mL | 2.4660 mL | |
| 40 mM | 0.0740 mL | 0.3699 mL | 0.7398 mL | 1.8495 mL | |
| 50 mM | 0.0592 mL | 0.2959 mL | 0.5918 mL | 1.4796 mL | |
| 60 mM | 0.0493 mL | 0.2466 mL | 0.4932 mL | 1.2330 mL | |
| 80 mM | 0.0370 mL | 0.1849 mL | 0.3699 mL | 0.9247 mL | |
| 100 mM | 0.0296 mL | 0.1480 mL | 0.2959 mL | 0.7398 mL |
AC-42 hydrochloride Related Classifications
HY-118806A Related Classifications
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