2. Protein Tyrosine Kinase/RTK
  3. FLT3
  4. MZH29

MZH29 is a potent and orally active FLT3 inhibitor. MZH29 shows inhibitory effects on wild-type and mutant FLT3, including the FLT3-ITD, FLT3-D835H/Y/V and FLT3-K663Q mutants. MZH29 retains its potent inhibitory effect against the FLT3-ITD/F691L mutation, a drug resistance mutation against the well-known FLT3 inhibitor, AC220 (HY-13001). MZH29 can be used for the research of cancer, such as acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

MZH29

MZH29 Chemical Structure

CAS No. : 2089590-80-5

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MZH29 Related Antibodies

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Description

MZH29 is a potent and orally active FLT3 inhibitor. MZH29 shows inhibitory effects on wild-type and mutant FLT3, including the FLT3-ITD, FLT3-D835H/Y/V and FLT3-K663Q mutants. MZH29 retains its potent inhibitory effect against the FLT3-ITD/F691L mutation, a drug resistance mutation against the well-known FLT3 inhibitor, AC220 (HY-13001). MZH29 can be used for the research of cancer, such as acute myeloid leukemia (AML)[1].

Cellular Effect
Cell Line Type Value Description References
BaF3 IC50
0.17 nM
Compound: 10; MZH29
Antiproliferative activity against mouse BaF3 cells expressing FLT3-D835H
Antiproliferative activity against mouse BaF3 cells expressing FLT3-D835H
[PMID: 33719439]
BaF3 IC50
0.19 nM
Compound: 10; MZH29
Antiproliferative activity against mouse BaF3 cells expressing FLT3-D835Y
Antiproliferative activity against mouse BaF3 cells expressing FLT3-D835Y
[PMID: 33719439]
BaF3 IC50
0.22 nM
Compound: 10; MZH29
Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD
Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD
[PMID: 33719439]
BaF3 IC50
1.1 nM
Compound: 10; MZH29
Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD-F691L
Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD-F691L
[PMID: 33719439]
BaF3 IC50
2.5 nM
Compound: 10; MZH29
Antiproliferative activity against mouse BaF3 cells expressing FLT3-D835V
Antiproliferative activity against mouse BaF3 cells expressing FLT3-D835V
[PMID: 33719439]
BaF3 IC50
22 nM
Compound: 10; MZH29
Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD-D835Y
Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD-D835Y
[PMID: 33719439]
MOLM-13 IC50
0.24 nM
Compound: MZH29
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 32659083]
MOLM-14 IC50
0.13 nM
Compound: 10; MZH29
Antiproliferative activity against human MOLM-14 cells
Antiproliferative activity against human MOLM-14 cells
[PMID: 33719439]
MV4-11 IC50
0.14 nM
Compound: 10; MZH29
Cytotoxicity against human MV4-11 cells
Cytotoxicity against human MV4-11 cells
[PMID: 33719439]
MV4-11 IC50
0.14 nM
Compound: MZH29
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 32659083]
In Vivo

MZH29 (1 mg/kg, p.o.) causes complete tumor regression and extends survival in a mouse model of AML with less toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

560.62

Formula

C31H33FN4O5
CAS No.
SMILES

O=C(NC1=CC=CC(C)=C1)NC2=CC=C(OC3=CC=NC4=CC(OCCCN5CCOCC5)=C(OC)C=C34)C(F)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MZH29 Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MZH292089590-80-5MZH 29MZH-29FLT3Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3FLT3-ITDFLT3-D835H/Y/VFLT3-K663QFLT3-ITD/F691Lacute myeloid leukemiaAMLcancerInhibitorinhibitorinhibit

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HY-115443
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