Ac-Lys(CoA)-NH2
Based on 1 publication(s) in Google Scholar
Ac-Lys(CoA)-NH2 (Ac-Lys(coenzyme A)-NH2 TFA) is a selective p300 histone acetyltransferase (HAT) inhibitor with an IC50 of approximately 50 nM or 500 nM.
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- No. CAS: 279256-67-6
- Fòrmula: C31H53N10O19P3S
- Peso molecular:994.79
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Other In-stock Forms of Ac-Lys(CoA)-NH2
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Actividad biológica
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Ac-Lys(CoA)-NH2
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
p300 ~50-500 nM (IC50) |
In Vitro
Ac-Lys(CoA)-NH2 (1 min) is a potent and selective p300 inhibitor with an IC50 of 0.5 µM, while its inhibitory effect on PCAF is much weaker, with an IC50 of 200 µM[2].
Ac-Lys(CoA)-NH2 (0-120 pmol per oocyte; 12 h) selectively inhibits p300-activated transcription in Xenopus oocytes with an IC50 of approximately 30 pmol/cell, while exerting only a minimal effect on PCAF-mediated activation[2].
Ac-Lys(CoA)-NH2 TFA is a potent p300/CBP HAT inhibitor with Ki = 19 nM in biochemical assays[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 279256-67-6
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Peso molecular 994.79
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Fòrmula C31H53N10O19P3S
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SMILES
O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSCC(NCCCC[C@@H](C(N)=O)NC(C)=O)=O)=O)=O)(O)=O)(O)=O)O[C@H]1N2C=NC3=C(N)N=CN=C32
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Synonyms
Ac-Lys(coenzyme A)-NH2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Rep
DOCK1 inhibitor Box5 (TFA) suppresses proliferation of AML cell lines and prolongs survival in AML xenograft models. [Abstract]2026 May 11;16(1):21377. PMID: 42108312
Pureza y Documentación
Referencias
[1]. Cebrat M, et al. Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300. Bioorganic & medicinal chemistry. 2003 Jul 31;11(15):3307-13. [Content Brief]
[2]. Lau OD, et al. HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Molecular cell. 2000 Mar;5(3):589-95. [Content Brief]
[3]. Cole PA, et al. Chemical probes for histone-modifying enzymes. Nature chemical biology. 2008 Oct;4(10):590-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ac-Lys(CoA)-NH2 Related Classifications
HY-CE01449 Related Classifications
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Keywords
- Ac-Lys(CoA)-NH2
- 279256-67-6
- Ac-Lys(coenzyme A)-NH2
- Histone Acetyltransferase
- HATs
- HAT
- C. elegans development
- HAT inhibitor
- PCAF
- acetyl transfer
- bisubstrate analog
- chromatin-template transcription
- muscle cell differentiation
- p300/CBP histone acetyltransferase
- p73 acetylation
- transcriptional activation
- Inhibitor
- inhibitor
- inhibit