279256-67-6
279256-67-6
Chemical Structure
Ac-Lys(CoA)-NH2
Synonym(s): Ac-Lys(coenzyme A)-NH2
- CAS. Nr.: 279256-67-6
- Formula:C31H53N10O19P3S
- Molecular Weight:994.79
InChIKey: YGZKIOPJGFQDSR-QGSWMBNESA-N
SMILES: O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSCC(NCCCC[C@@H](C(N)=O)NC(C)=O)=O)=O)=O)(O)=O)(O)=O)O[C@H]1N2C=NC3=C(N)N=CN=C32
Biological Activity: Ac-Lys(CoA)-NH2 (Ac-Lys(coenzyme A)-NH2 TFA) is a selective p300 histone acetyltransferase (HAT) inhibitor with an IC50 of approximately 50 nM or 500 nM[1][2][3].
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Ac-Lys(CoA)-NH2 | Ac-Lys(CoA)-NH2 (Ac-Lys(coenzyme A)-NH2 TFA) is a selective p300 histone acetyltransferase (HAT) inhibitor with an IC50 of approximately 50 nM or 500 nM. | |||||||||||||||||||||
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References
- [1]. Cebrat M, et al. Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300. Bioorganic & medicinal chemistry. 2003 Jul 31;11(15):3307-13. [Content Brief]
- [2]. Lau OD, et al. HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Molecular cell. 2000 Mar;5(3):589-95. [Content Brief]
- [3]. Cole PA, et al. Chemical probes for histone-modifying enzymes. Nature chemical biology. 2008 Oct;4(10):590-7. [Content Brief]
