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Cat. No.: HY-180462

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TCCNeu5Ac

TCCNeu5Ac (compound H-56) is a high-affinity and selective trisaccharide glycan ligand for Siglec-1 (CD169). TCCNeu5Ac azide can be conjugated to lipids to selectively target cells expressing either murine or human CD169 in vitro, exhibiting in vivo targeting to CD169-positive macrophages. TCCNeu5Ac can be used for in vivo macrophage delivery.

For research use only. We do not sell to patients.

CAS No.: 3036471-42-5
Formula: C₃₉H₅₁N₆NaO₂₀S
Molecular Weight:978.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

TCCNeu5Ac Chemical Structure

CAS No.: 3036471-42-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

TCCNeu5Ac (compound H-56) is a high-affinity and selective trisaccharide glycan ligand for Siglec-1 (CD169)^[1]^[2]. TCCNeu5Ac azide can be conjugated to lipids to selectively target cells expressing either murine or human CD169 in vitro, exhibiting in vivo targeting to CD169-positive macrophages. TCCNeu5Ac can be used for in vivo macrophage delivery^[3].

Chemical Information

CAS No. 3036471-42-5
Molecular Weight 978.91
Formula C₃₉H₅₁N₆NaO₂₀S
SMILES

OC([C@@]1(O[C@@]([C@@H]([C@H](C1)O)NC(C)=O)([H])[C@H](O)[C@H](O)CNC(C2=CC(COC3=CC=CC=C34)=C4S2)=O)O[C@@H]5[C@H]([C@@H](O[C@@H]([C@@H]5O)CO)O[C@@H]6[C@H](O[C@H]([C@@H]([C@H]6O)NC(C)=O)OCCN=[N+]=[N-])CO[Na])O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Namita BISARIA, et al. Glycan conjugate compositions and methods. WO2024086767. 2024-04-25.

[2]. Xu Yan, et al. A kind of affine three sugar compounds of CD169 and preparation method thereof. CN110041381. 2019-07-23.

[3]. Nycholat CM, et al. In silico-aided design of a glycan ligand of sialoadhesin for in vivo targeting of macrophages. J Am Chem Soc. 2012 Sep 26;134(38):15696-9. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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