Ac4GalNAl
Based on 1 Customer Validation
Ac4GalNAl is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. Ac4GalNAl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity: 99.78%
- CAS No.: 1673590-09-4
- Formula: C19H25NO10
- Molecular Weight:427.40
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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Alkyl-Chain |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1673590-09-4
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Appearance Solid
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Molecular Weight 427.40
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Formula C19H25NO10
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Color White to off-white
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SMILES
O=C(N[C@@H]1[C@H]([C@H]([C@H](O[C@H]1OC(C)=O)COC(C)=O)OC(C)=O)OC(C)=O)CCC#C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (233.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3397 mL | 11.6986 mL | 23.3973 mL | 58.4932 mL |
| 5 mM | 0.4679 mL | 2.3397 mL | 4.6795 mL | 11.6986 mL | |
| 10 mM | 0.2340 mL | 1.1699 mL | 2.3397 mL | 5.8493 mL | |
| 15 mM | 0.1560 mL | 0.7799 mL | 1.5598 mL | 3.8995 mL | |
| 20 mM | 0.1170 mL | 0.5849 mL | 1.1699 mL | 2.9247 mL | |
| 25 mM | 0.0936 mL | 0.4679 mL | 0.9359 mL | 2.3397 mL | |
| 30 mM | 0.0780 mL | 0.3900 mL | 0.7799 mL | 1.9498 mL | |
| 40 mM | 0.0585 mL | 0.2925 mL | 0.5849 mL | 1.4623 mL | |
| 50 mM | 0.0468 mL | 0.2340 mL | 0.4679 mL | 1.1699 mL | |
| 60 mM | 0.0390 mL | 0.1950 mL | 0.3900 mL | 0.9749 mL | |
| 80 mM | 0.0292 mL | 0.1462 mL | 0.2925 mL | 0.7312 mL | |
| 100 mM | 0.0234 mL | 0.1170 mL | 0.2340 mL | 0.5849 mL |
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