2. PROTAC
  3. PROTAC Linkers
  4. Ac4GalNAl

Ac4GalNAl is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. Ac4GalNAl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Ac4GalNAl

Ac4GalNAl Chemical Structure

CAS No. : 1673590-09-4

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Based on 1 publication(s) in Google Scholar

Ac4GalNAl Related Antibodies

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Description

Ac4GalNAl is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Ac4GalNAl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

Alkyl-Chain

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ac4GalNAl Related Antibodies
Molecular Weight

427.40

Formula

C19H25NO10
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@@H]1[C@H]([C@H]([C@H](O[C@H]1OC(C)=O)COC(C)=O)OC(C)=O)OC(C)=O)CCC#C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (233.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3397 mL 11.6986 mL 23.3973 mL
5 mM 0.4679 mL 2.3397 mL 4.6795 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3397 mL 11.6986 mL 23.3973 mL 58.4932 mL
5 mM 0.4679 mL 2.3397 mL 4.6795 mL 11.6986 mL
10 mM 0.2340 mL 1.1699 mL 2.3397 mL 5.8493 mL
15 mM 0.1560 mL 0.7799 mL 1.5598 mL 3.8995 mL
20 mM 0.1170 mL 0.5849 mL 1.1699 mL 2.9247 mL
25 mM 0.0936 mL 0.4679 mL 0.9359 mL 2.3397 mL
30 mM 0.0780 mL 0.3900 mL 0.7799 mL 1.9498 mL
40 mM 0.0585 mL 0.2925 mL 0.5849 mL 1.4623 mL
50 mM 0.0468 mL 0.2340 mL 0.4679 mL 1.1699 mL
60 mM 0.0390 mL 0.1950 mL 0.3900 mL 0.9749 mL
80 mM 0.0292 mL 0.1462 mL 0.2925 mL 0.7312 mL
100 mM 0.0234 mL 0.1170 mL 0.2340 mL 0.5849 mL
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Ac4GalNAl Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac4GalNAl1673590-09-4PROTAC LinkersInhibitorinhibitorinhibit

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