AC-263093 free base
Based on 1 Customer Validation
AC-263093 free base (AC-093) functionally activates NPFFR2 and blocks activation of NPFFR1 with pKis of 6.9 and 7.0, respectively. AC-263093 free base has the potential for reversing opiate tolerance research.
.
For research use only. We do not sell to patients.
- Purity: 99.66%
- CAS No.: 849459-86-5
- Formula: C8H8Br2N4
- Molecular Weight:319.98
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
GPCR/G Protein Compound Library
HY-L006
-
Immunology/Inflammation Compound Library
HY-L007
-
Cysteine Targeted Covalent Library
HY-L153
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Lactylation Compound Library
HY-L249
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| COS-1 | EC50 |
2195 nM
Compound: AC-093
|
Agonist activity at human NPFF2 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting
Agonist activity at human NPFF2 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting
|
[PMID: 22708927] |
| COS-1 | EC50 |
527 nM
Compound: AC-093
|
Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting
Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting
|
[PMID: 22708927] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male Sprague-Dawley rats weighing 405±27 g[1]
-
Dosage:10 mg/kg
-
Administration:IP; single dose
-
Result:Pre-treated decreased the Morphine (5 mg/kg; 7 days) analgesia scores.
Chemical Information
-
CAS No. 849459-86-5
-
Appearance Solid
-
Molecular Weight 319.98
-
Formula C8H8Br2N4
-
Color White to off-white
-
SMILES
BrC1=CC=C(/C=N/NC(N)=N)C=C1Br
-
Synonyms
AC-093
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (390.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
-
Data Sheet (269 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1252 mL | 15.6260 mL | 31.2520 mL | 78.1299 mL |
| 5 mM | 0.6250 mL | 3.1252 mL | 6.2504 mL | 15.6260 mL | |
| 10 mM | 0.3125 mL | 1.5626 mL | 3.1252 mL | 7.8130 mL | |
| 15 mM | 0.2083 mL | 1.0417 mL | 2.0835 mL | 5.2087 mL | |
| 20 mM | 0.1563 mL | 0.7813 mL | 1.5626 mL | 3.9065 mL | |
| 25 mM | 0.1250 mL | 0.6250 mL | 1.2501 mL | 3.1252 mL | |
| 30 mM | 0.1042 mL | 0.5209 mL | 1.0417 mL | 2.6043 mL | |
| 40 mM | 0.0781 mL | 0.3906 mL | 0.7813 mL | 1.9532 mL | |
| 50 mM | 0.0625 mL | 0.3125 mL | 0.6250 mL | 1.5626 mL | |
| 60 mM | 0.0521 mL | 0.2604 mL | 0.5209 mL | 1.3022 mL | |
| 80 mM | 0.0391 mL | 0.1953 mL | 0.3906 mL | 0.9766 mL | |
| 100 mM | 0.0313 mL | 0.1563 mL | 0.3125 mL | 0.7813 mL |
Powered by Bioz