1. Neuronal Signaling
  2. Amyloid-β
  3. AC 253

AC 253 

Cat. No.: HY-P2285
Handling Instructions

AC 253 is an Amylin (AMY3) receptor antagonist, inhibiting andrenomedulin-stimulated cAMP production. AC 253 protects against oligomeric Aβ-induced increase in intracellular Ca2+, activation of PKA, MAPK, Akt and cFOS and cell death in neuronal cell culture. AC 253 blocks electrophysiological effects of Aβ.

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AC 253 Chemical Structure

AC 253 Chemical Structure

CAS No. : 151804-79-4

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Description

AC 253 is an Amylin (AMY3) receptor antagonist, inhibiting andrenomedulin-stimulated cAMP production. AC 253 protects against oligomeric Aβ-induced increase in intracellular Ca2+, activation of PKA, MAPK, Akt and cFOS and cell death in neuronal cell culture. AC 253 blocks electrophysiological effects of Aβ.

Molecular Weight

2847.11

Formula

C₁₂₂H₁₉₆N₄₀O₃₉

CAS No.

151804-79-4

Sequence

Ac-Leu-Gly-Arg-Leu-Ser-Gln-Glu-Leu-His-Arg-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2

Sequence Shortening

Ac-LGRLSQELHRLQTYPRTNTGSNTY-NH2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AC 253AC253AC-253Amyloid-ββ-amyloid peptideAbetaInhibitorinhibitorinhibit

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