Cyclic AC253
Based on 1 Customer Validation
Cyclic AC253 is an antagonist for amylin receptor, with IC50 of 0.3 μM. Cyclic AC253 exhibits neuroprotective efficacy against Aβ toxicity and abrogates Aβ-induced impairment of hippocampal long-term potentiation. Cyclic AC253 penetrate blood-brain barrier (BBB).
For research use only. We do not sell to patients.
- Purity: 99.83%
- Formula: C126H202N42O40S2
- Molecular Weight:3009.34
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Alzheimer’s Disease in TgCRND8 mice model[1]
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Dosage:200 μg/kg
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Administration:ip, 3 times a week for 10 weeks
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Result:Improved cognitive deficits.
Chemical Information
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Appearance Solid
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Molecular Weight 3009.34
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Formula C126H202N42O40S2
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Color White to off-white
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Sequence
Phe-Leu-Pro-Leu-Leu-Ile-Leu-Gly-Ser-Leu-Leu-Met-Thr-Pro-Pro-Val-Ile-Gln-Ala-Ile-His-Asp-Ala-Gln-Arg-NH2 (Disulfide bridge: Cys1-Cys26)
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Sequence Shortening
CLGRLSQELHRLQTYPRTNTGSNTYC-NH2 (Disulfide bridge: Cys1-Cys26)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (33.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.3323 mL | 1.6615 mL | 3.3230 mL | 8.3075 mL |
| 5 mM | 0.0665 mL | 0.3323 mL | 0.6646 mL | 1.6615 mL | |
| 10 mM | 0.0332 mL | 0.1661 mL | 0.3323 mL | 0.8307 mL | |
| 15 mM | 0.0222 mL | 0.1108 mL | 0.2215 mL | 0.5538 mL | |
| 20 mM | 0.0166 mL | 0.0831 mL | 0.1661 mL | 0.4154 mL | |
| 25 mM | 0.0133 mL | 0.0665 mL | 0.1329 mL | 0.3323 mL | |
| 30 mM | 0.0111 mL | 0.0554 mL | 0.1108 mL | 0.2769 mL |
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