2. GPCR/G Protein
  3. Amylin Receptor
  4. Cyclic AC253

Cyclic AC253 is an antagonist for amylin receptor, with IC50 of 0.3 μM. Cyclic AC253 exhibits neuroprotective efficacy against Aβ toxicity and abrogates Aβ-induced impairment of hippocampal long-term potentiation. Cyclic AC253 penetrate blood-brain barrier (BBB).

For research use only. We do not sell to patients.

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Cyclic AC253 Chemical Structure

Cyclic AC253 Chemical Structure

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Cyclic AC253 Related Antibodies

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Description

Cyclic AC253 is an antagonist for amylin receptor, with IC50 of 0.3 μM. Cyclic AC253 exhibits neuroprotective efficacy against Aβ toxicity and abrogates Aβ-induced impairment of hippocampal long-term potentiation. Cyclic AC253 penetrate blood-brain barrier (BBB)[1].

In Vitro

Cyclic AC253 (0-10 μM) protects neuronal cells HFNs and N2a from Aβ1–42-induced cytotoxicity and apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclic AC253 Related Antibodies
In Vivo

Cyclic AC253 (200 μg/kg, ip, 3 times a week for 10 weeks) improves cognitive deficits in TgCRND8 mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Alzheimer’s Disease in TgCRND8 mice model[1]
Dosage: 200 μg/kg
Administration: ip, 3 times a week for 10 weeks
Result: Improved cognitive deficits.
Molecular Weight

3009.34

Formula

C126H202N42O40S2
Unlabeled Cas

Sequence

Phe-Leu-Pro-Leu-Leu-Ile-Leu-Gly-Ser-Leu-Leu-Met-Thr-Pro-Pro-Val-Ile-Gln-Ala-Ile-His-Asp-Ala-Gln-Arg-NH2 (Disulfide bridge: Cys1-Cys26)
Sequence Shortening

CLGRLSQELHRLQTYPRTNTGSNTYC-NH2 (Disulfide bridge: Cys1-Cys26)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cyclic AC253 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclic AC253Cyclic AC 253Cyclic AC-253Amylin ReceptorAMYRAlzheimer's DiseaseTgCRND8 miceBBB penetrateHEK29Inhibitorinhibitorinhibit

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Cyclic AC253
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HY-P10235
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