1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
    Neurotensin Receptor
  3. Levocabastine hydrochloride

Levocabastine hydrochloride (Synonyms: R 50547 hydrochloride)

Cat. No.: HY-14277A Purity: >98.0%
Handling Instructions

Levocabastine hydrochloride is a long acting, highly potent and selective histamine H1-receptor antagonist with anti-allergic activity. Levocabastine hydrochloride is also a selective, high affinity neurotensin receptor subtype 2 (NTR2) antagonist, with a Ki of 17 nM for mNTR2.

For research use only. We do not sell to patients.

Levocabastine hydrochloride Chemical Structure

Levocabastine hydrochloride Chemical Structure

CAS No. : 79547-78-7

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5 mg USD 270 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Levocabastine hydrochloride is a long acting, highly potent and selective histamine H1-receptor antagonist with anti-allergic activity. Levocabastine hydrochloride is also a selective, high affinity neurotensin receptor subtype 2 (NTR2) antagonist, with a Ki of 17 nM for mNTR2[1][2].

IC50 & Target[1]

H1 Receptor

 

NTR2

17 nM (Ki)

In Vivo

Levocabastine (0.25 mg/kg; i.p.; twice a day for five successive days; guinea-pigs) inhibits the virus-induced airway hyperresponsiveness, suppresses the influx of broncho-alveolar cells and increase in albumin content, and corrects the reduced chemiluminescence production by broncho-alveolar cells in response to zymosan[1].
In mice that receivedβ-LT, Levocabastine (0.05 mg/kg; i.p.) blocks the anxiolytic effect of β-LT and the number of head-dips decreased[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

456.98

Formula

C₂₆H₃₀ClFN₂O₂

CAS No.

79547-78-7

SMILES

O=C([[email protected]@]1(C2=CC=CC=C2)[[email protected]](C)CN(C3CCC(C4=CC=C(F)C=C4)(C#N)CC3)CC1)O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: >98.0%

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Keywords:

LevocabastineR 50547R50547R-50547Histamine ReceptorNeurotensin Receptoranti-allergicanxiolyticeffectinflammatoryselectiveInhibitorinhibitorinhibit

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Product Name:
Levocabastine hydrochloride
Cat. No.:
HY-14277A
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