Sirtratumab
Based on 1 Customer Validation
Sirtratumab (AGS15C; Ha15-10ac12; Ha15-10ac12.1) is a SLITRK6-specific humanized IgG2 monoclonal antibody, and serves as the parental antibody of the ADC ASG-15ME (HY-P99595). Sirtratumab is applicable for cancer research.
For research use only. We do not sell to patients.
- Purity: ≥99.0%
- CAS No.: 1824663-82-2
- Molecular Weight:146 kDa
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG2 kappa
Human
SLITRK6
Sirtratumab (0.00067-40 nmol/L; overnight at 4°C) binds with high affinity to SLITRK6 expressed on SW-780 bladder transitional cell carcinoma cells, with a Kd of 0.015 nmol/L[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
-
Human IgG2 kappa
ELISA, FACS, Functional assay
-
Flow Cytometry analysis of SK-N-SH cells labelling SLITRK6 (red) with Sirtratumab (anti-SLITRK6) (HY-P99964). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG2 kappa (HY-P99002). Black-Unlabelled control, cells without incubation with primary antibody. -
Immobilized HY-P77208 SLITRK6 Protein, Human (HEK293, His) can bind Sirtratumab. The EC50 for this effect is 19.86 ng/mL.
Chemical Information
-
CAS No. 1824663-82-2
-
Appearance Liquid
-
Molecular Weight 146 kDa
-
Color Colorless to light yellow
-
SMILES
[Sirtratumab]
-
Synonyms
AGS15C; Ha15-10ac12; Ha15-10ac12.1
-
Shipping
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
-
Data Sheet (256 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)