2. Metabolic Enzyme/Protease
  3. Proteasome
  4. Ac-Leu-Leu-Norleucinol

Ac-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen (HY-66005) induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST).

For research use only. We do not sell to patients.

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Ac-Leu-Leu-Norleucinol Chemical Structure

Ac-Leu-Leu-Norleucinol Chemical Structure

CAS No. : 148333-42-0

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Ac-Leu-Leu-Norleucinol Related Antibodies

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Description

Ac-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen (HY-66005) induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST)[1].

IC50 & Target

Calpain[1]
In Vivo

Ac-Leu-Leu-Norleucinol (10 mg/kg, 20 mg/kg; i.p.; single dose) effectively prevents Acetaminophen (HY-66005)-induced acute liver injury in mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Acute liver injury model induced by Acetaminophen (APAP) in C57BL/6 mice (18-22 g)[1]
Dosage: 10 mg/kg, 20 mg/kg; accompanied with 300 mg/kg APAP (i.p.)
Administration: Intraperitoneal injection; collected tissue samples 24 hr after
Result: Significantly reduced APAP-induced stem cell necrosis and lowered the level of glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST).
Injection alone did not cause pathological changes in the liver.
Molecular Weight

399.52

Formula

C20H37N3O5
CAS No.
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Purity & Documentation
References
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Ac-Leu-Leu-Norleucinol Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac-Leu-Leu-Norleucinol148333-42-0Proteasomeacetaminophenglutamic-oxalacetic transamineaseglutamic-pyruvic transaminaseInhibitorinhibitorinhibit

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