Ac-Leu-Leu-Norleucinol
Based on 1 Customer Validation
Ac-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen (HY-66005) induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST).
For research use only. We do not sell to patients.
- CAS No.: 148333-42-0
- Formula: C20H37N3O5
- Molecular Weight:399.52
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Calpain[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Acute liver injury model induced by Acetaminophen (APAP) in C57BL/6 mice (18-22 g)[1]
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Dosage:10 mg/kg, 20 mg/kg; accompanied with 300 mg/kg APAP (i.p.)
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Administration:Intraperitoneal injection; collected tissue samples 24 hr after
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Result:Significantly reduced APAP-induced stem cell necrosis and lowered the level of glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST).
Injection alone did not cause pathological changes in the liver.
Chemical Information
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CAS No. 148333-42-0
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Appearance Solid
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Molecular Weight 399.52
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Formula C20H37N3O5
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Color White to off-white
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (250.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.5030 mL | 12.5150 mL | 25.0300 mL | 62.5751 mL |
| 5 mM | 0.5006 mL | 2.5030 mL | 5.0060 mL | 12.5150 mL | |
| 10 mM | 0.2503 mL | 1.2515 mL | 2.5030 mL | 6.2575 mL | |
| 15 mM | 0.1669 mL | 0.8343 mL | 1.6687 mL | 4.1717 mL | |
| 20 mM | 0.1252 mL | 0.6258 mL | 1.2515 mL | 3.1288 mL | |
| 25 mM | 0.1001 mL | 0.5006 mL | 1.0012 mL | 2.5030 mL | |
| 30 mM | 0.0834 mL | 0.4172 mL | 0.8343 mL | 2.0858 mL | |
| 40 mM | 0.0626 mL | 0.3129 mL | 0.6258 mL | 1.5644 mL | |
| 50 mM | 0.0501 mL | 0.2503 mL | 0.5006 mL | 1.2515 mL | |
| 60 mM | 0.0417 mL | 0.2086 mL | 0.4172 mL | 1.0429 mL | |
| 80 mM | 0.0313 mL | 0.1564 mL | 0.3129 mL | 0.7822 mL | |
| 100 mM | 0.0250 mL | 0.1252 mL | 0.2503 mL | 0.6258 mL |
Ac-Leu-Leu-Norleucinol Related Classifications
HY-P3690 Related Classifications
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