Ac22(Az8)2
Ac22(Az8)2 is a selective BCRP inhibitor (EC50: 1-2 nM). Ac22(Az8)2 can restore the drug sensitivity of BCRP-overexpressing cells by inhibiting BCRP-ATPase activity, blocking drug efflux, and increasing intracellular drug accumulation. Ac22(Az8)2 can be used in the research of BCRP-mediated multidrug-resistant cancers.
For research use only. We do not sell to patients.
- CAS No.: 2377858-65-4
- Formula: C66H56N6O14
- Molecular Weight:1157.18
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HFF-1 | IC50 |
>100 μM
Compound: Ac22(Az8)2
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Cytotoxicity against human HFF1 cells assessed as reduction in cell viability
Cytotoxicity against human HFF1 cells assessed as reduction in cell viability
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[PMID: 31465686] |
| NIH3T3 | IC50 |
>100 μM
Compound: Ac22(Az8)2
|
Cytotoxicity against mouse 3T3 cells assessed as reduction in cell viability
Cytotoxicity against mouse 3T3 cells assessed as reduction in cell viability
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[PMID: 31465686] |
Chemical Information
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CAS No. 2377858-65-4
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Molecular Weight 1157.18
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Formula C66H56N6O14
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SMILES
O=C(C(OCC1=CC=CC(C(OC)=O)=C1)=C(C2=CC=C(OCCOCCN3N=NC(C4=CC(C5=CN(CCOCCOC6=CC=C(C7=C(OCC8=CC(C(OC)=O)=CC=C8)C(C(C=CC=C9)=C9O7)=O)C=C6)N=N5)=CC=C4)=C3)C=C2)O%10)C%11=C%10C=CC=C%11
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ac22(Az8)2 Related Classifications
HY-136940 Related Classifications
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