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Cat. No.: HY-136940

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Ac22(Az8)2

Ac22(Az8)2 is a selective BCRP inhibitor (EC₅₀: 1-2 nM). Ac22(Az8)2 can restore the drug sensitivity of BCRP-overexpressing cells by inhibiting BCRP-ATPase activity, blocking drug efflux, and increasing intracellular drug accumulation. Ac22(Az8)2 can be used in the research of BCRP-mediated multidrug-resistant cancers.

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CAS No.: 2377858-65-4
화학식: C₆₆H₅₆N₆O₁₄
분자량:1157.18

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Ac22(Az8)2 Chemical Structure

CAS No.: 2377858-65-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
HFF-1	IC₅₀	>100 μM Compound: Ac22(Az8)2	Cytotoxicity against human HFF1 cells assessed as reduction in cell viability Cytotoxicity against human HFF1 cells assessed as reduction in cell viability	[PMID: 31465686]
NIH3T3	IC₅₀	>100 μM Compound: Ac22(Az8)2	Cytotoxicity against mouse 3T3 cells assessed as reduction in cell viability Cytotoxicity against mouse 3T3 cells assessed as reduction in cell viability	[PMID: 31465686]

Chemical Information

CAS No. 2377858-65-4
분자량 1157.18
화학식 C₆₆H₅₆N₆O₁₄
SMILES

O=C(C(OCC1=CC=CC(C(OC)=O)=C1)=C(C2=CC=C(OCCOCCN3N=NC(C4=CC(C5=CN(CCOCCOC6=CC=C(C7=C(OCC8=CC(C(OC)=O)=CC=C8)C(C(C=CC=C9)=C9O7)=O)C=C6)N=N5)=CC=C4)=C3)C=C2)O%10)C%11=C%10C=CC=C%11
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhu X, et al. Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors. J Med Chem. 2019 Sep 26;62(18):8578-8608. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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