2377858-65-4
Chemical Structure
Ac22(Az8)2
- CAS. Nr.: 2377858-65-4
- Formula:C66H56N6O14
- Molecular Weight:1157.18
IUPAC Name: dimethyl 3,3'-(((((((((1,3-phenylenebis(1H-1,2,3-triazole-4,1-diyl))bis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(oxy))bis(4,1-phenylene))bis(4-oxo-4H-chromene-2,3-diyl))bis(oxy))bis(methylene))dibenzoate
InChIKey: VCMDBWMGCBGSNR-UHFFFAOYSA-N
SMILES: O=C(C(OCC1=CC=CC(C(OC)=O)=C1)=C(C2=CC=C(OCCOCCN3N=NC(C4=CC(C5=CN(CCOCCOC6=CC=C(C7=C(OCC8=CC(C(OC)=O)=CC=C8)C(C(C=CC=C9)=C9O7)=O)C=C6)N=N5)=CC=C4)=C3)C=C2)O%10)C%11=C%10C=CC=C%11
Biological Activity: Ac22(Az8)2 is a selective BCRP inhibitor (EC50: 1-2 nM). Ac22(Az8)2 can restore the drug sensitivity of BCRP-overexpressing cells by inhibiting BCRP-ATPase activity, blocking drug efflux, and increasing intracellular drug accumulation. Ac22(Az8)2 can be used in the research of BCRP-mediated multidrug-resistant cancers[1].
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Ac22(Az8)2 | Ac22(Az8)2 is a selective BCRP inhibitor (EC50: 1-2 nM). Ac22(Az8)2 can restore the drug sensitivity of BCRP-overexpressing cells by inhibiting BCRP-ATPase activity, blocking drug efflux, and increasing intracellular drug accumulation. Ac22(Az8)2 can be used in the research of BCRP-mediated multidrug-resistant cancers. | |||||||||||||||||||||
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Keywords
