2. PI3K/Akt/mTOR Epigenetics Cell Cycle/DNA Damage
  3. PI3K HDAC Akt Histone Methyltransferase
  4. SJY26

SJY26 is a PI3K/HDAC dual-target inhibitor with IC50s of 0.59 nM (PI3Kα and PI3Kδ), 2.02 nM (PI3Kγ), 12.69 nM (PI3Kβ) and 114 nM (HDAC1). SJY26 exhibits potent broad-spectrum anti-proliferative activity, and is particularly sensitive to Jurkat and PC9R cells. SJY26 inhibited the migration of PC9R cells, arrested the cell cycle and induced cell apoptosis. SJY26 reduces AKT phosphorylation, and decreases histone H3 deacetylation (Ac-H3). SJY26 can be used for the studies of non-small cell lung cancer and leukemia.

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SJY26

SJY26 Chemical Structure

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SJY26 Related Antibodies

Top Publications Citing Use of Products

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Akt Akt1 Akt2 Akt3

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EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

SJY26 is a PI3K/HDAC dual-target inhibitor with IC50s of 0.59 nM (PI3Kα and PI3Kδ), 2.02 nM (PI3Kγ), 12.69 nM (PI3Kβ) and 114 nM (HDAC1). SJY26 exhibits potent broad-spectrum anti-proliferative activity, and is particularly sensitive to Jurkat and PC9R cells. SJY26 inhibited the migration of PC9R cells, arrested the cell cycle and induced cell apoptosis. SJY26 reduces AKT phosphorylation, and decreases histone H3 deacetylation (Ac-H3). SJY26 can be used for the studies of non-small cell lung cancer and leukemia[1].

IC50 & Target[1]

PI3Kα

0.59 nM (IC50)

PI3Kδ

0.59 nM (IC50)

PI3Kγ

2.02 nM (IC50)

PI3Kβ

12.69 nM (IC50)

HDAC1

114 nM (IC50)

In Vitro

SJY26 (24 h) exhibits potent inhibitory activity against Jurkat, PC9R, MCF-7 and K562 cells with IC50s of 0.38 μM, 0.59 μM, 1.98 μM and 4.30 μM[1].
SJY26 (1.25-2.5 μM, 0-48 h) effectively inhibits the migration ability of PC9R cells in a concentration-dependent manner[1].
SJY26 (2.5 μM, 24 h) arrests PC9R cells in the G2/M phase, preventing them from entering mitosis and completing proliferation[1].
SJY26 (2.5-5 μM, 48 h) induces cell apoptosis in a concentration-dependent manner in PC9R cells[1].
SJY26 (2.5-5 μM, 24 h) down-regulates the PI3K-AKT signaling pathway while up-regulates the level of histone acetylation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SJY26 Related Antibodies

Cell Migration Assay [1]

Cell Line: PC9R cells
Concentration: 1.25 μM and 2.5 μM
Incubation Time: 0, 24 and 48 h
Result: Effectively inhibited the migration ability of PC9R cells in a concentration-dependent manner.

Cell Cycle Analysis[1]

Cell Line: PC9R cells
Concentration: 2.5 μM
Incubation Time: 24 h
Result: Significantly increased the proportion of cells in the G2/M phase.

Apoptosis Analysis[1]

Cell Line: PC9R cells
Concentration: 2.5 μM and 5 μM
Incubation Time: 48 h
Result: Induced cell apoptosis in a concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: PC9R cells
Concentration: 2.5 μM and 5 μM
Incubation Time: 24 h
Result: Down-regulated the PI3K-AKT signaling pathway while up-regulated the level of histone acetylation.
Molecular Weight

680.68

Formula

C35H26F2N6O5S
SMILES

O=C(C1=CC=NC2=CC=C(C3=CC(NS(=O)(C4=CC=C(F)C=C4F)=O)=C(OC)N=C3)C=C12)NC5=CC=C(C(NC6=CC=CC=C6N)=O)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SJY26 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJY26SJY 26SJY-26PI3KHDACAktHistone MethyltransferasePhosphoinositide 3-kinaseHistone deacetylasesPKBProtein kinase BAntitumorDual-targetInhibitorinhibitorinhibit

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