1. PI3K/Akt/mTOR
  2. PDK-1
  3. (R)-PS210

(R)-PS210 

Cat. No.: HY-13856
Handling Instructions

(R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment.

For research use only. We do not sell to patients.

(R)-PS210 Chemical Structure

(R)-PS210 Chemical Structure

CAS No. : 1410101-89-1

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Description

(R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment[1].

IC50 & Target

AC50: 1.8 μM (PDK1)[1]

In Vitro

(R)-PS210 displays an AC50 value of 1.8 μM towards PDK1 in a Cell-Free Kinase Activity Assay. And the maximum activation of PDK1 compared to DMSO control of (R)-PS210 is 5.5 fold[1].

Molecular Weight

380.31

Formula

C₁₉H₁₅F₃O₅

CAS No.

1410101-89-1

SMILES

O=C(O)C([[email protected]](C1=CC=CC=C1)CC(C2=CC=C(C(F)(F)F)C=C2)=O)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(R)-PS210PDK-1Phosphoinositide dependent protein kinase-14h-eutomerenantiomerPDK1activatorPIKInhibitorinhibitorinhibit

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