2. PI3K/Akt/mTOR
  3. PDK-1
  4. (R)-PS210

(R)-PS210 

Cat. No.: HY-13856 Purity: 98.20% ee.: 98.52%
COA Handling Instructions

(R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment.

For research use only. We do not sell to patients.

(R)-PS210 Chemical Structure

(R)-PS210 Chemical Structure

CAS No. : 1410101-89-1

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Solution
10 mM * 1 mL in DMSO USD 275 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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Estimated Time of Arrival: December 31
Solid
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 390 In-stock
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25 mg USD 780 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1250 In-stock
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100 mg USD 1950 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

(R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment[1].

IC50 & Target

AC50: 1.8 μM (PDK1)[1]
In Vitro

(R)-PS210 displays an AC50 value of 1.8 μM towards PDK1 in a Cell-Free Kinase Activity Assay. And the maximum activation of PDK1 compared to DMSO control of (R)-PS210 is 5.5 fold[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

380.31

Appearance

Solid

Formula

C19H15F3O5
CAS No.
SMILES

O=C(O)C([[email protected]](C1=CC=CC=C1)CC(C2=CC=C(C(F)(F)F)C=C2)=O)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 230 mg/mL (604.77 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6294 mL 13.1472 mL 26.2943 mL
5 mM 0.5259 mL 2.6294 mL 5.2589 mL
10 mM 0.2629 mL 1.3147 mL 2.6294 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5.75 mg/mL (15.12 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5.75 mg/mL (15.12 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5.75 mg/mL (15.12 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

(R)-PS2101410101-89-1PDK-13-Phosphoinositide-dependent protein kinase 14h-eutomerenantiomerPDK1activatorPIKInhibitorinhibitorinhibit

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