1410101-89-1
1410101-89-1
Chemical Structure
(R)-PS210
- CAS 番号: 1410101-89-1
- Formula:C19H15F3O5
- Molecular Weight:380.31
IUPAC Name: (R)-2-(3-oxo-1-phenyl-3-(4-(trifluoromethyl)phenyl)propyl)malonic acid
InChIKey: MLJPLHGJBUWCBA-AWEZNQCLSA-N
SMILES: O=C(O)C([C@H](C1=CC=CC=C1)CC(C2=CC=C(C(F)(F)F)C=C2)=O)C(O)=O
Biological Activity: (R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of?PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment[1].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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(R)-PS210 | 98.09% | (R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of?PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment. | ||||||||||||||||||||
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CATPB | 99.90% | CATPB is a potent, selective free fatty acid receptor 2 (FFA2R/GPR43) antagonist. | ||||||||||||||||||||
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LY307452 | LY307452 is an active compound. | |||||||||||||||||||||
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PS210 | 98.03% | PS210 is a potent and selective PDK1 activator with a Kd of 3 μM and targets the PIF-binding pocket of PDK1. PS210 is inactive against other protein kinases, including PDK1 downstream signaling components such as S6K, PKB/Akt or GSK3. In cells, the prodrug of PS210 (PS423) acts as a substrate-selective inhibitor of PDK1, inhibiting the phosphorylation and activation of S6K. | ||||||||||||||||||||
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PS423 | 99.38% | PS423 is a prodrug of PS210, acting as a substrate-selective inhibitor of PDK1, inhibiting the phosphorylation and activation of S6K. PS210 is a potent and selective PDK1 activator targeting the PIF binding pocket of PDK1. | ||||||||||||||||||||
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Fenbufen | 98.50% | Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor. | ||||||||||||||||||||
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Daphneolone | Daphneolone is a phenolic compound. Daphneolone can be isolated from the roots of Daphneodora. Some Daphneolone analogues show anti-plant pathogenic fungi activities. | |||||||||||||||||||||
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(S)-2-amino-3-(4-benzoylphenyl)propanoic acid | 99.77% | (S)-2-amino-3-(4-benzoylphenyl)propanoic acid is an alanine derivative. | ||||||||||||||||||||
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11β-HSD1-IN-7 | 99.73% | 11β-HSD1-IN-7 (compound c10a) is a 11β HSD1 inhibitor with an IC50 value of 1.9 μM for human 11β HSD1. 11β-HSD1-IN-7 can be used for the research of diabetes and cognitive decline. | ||||||||||||||||||||
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1,3,5-Triphenylpentane-1,5-dione | 1,3,5-Triphenylpentane-1,5-dione is a metal-organic framework (MOF). | |||||||||||||||||||||
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MAO-B-IN-47 | MAO-B-IN-47 is a selective monoamine oxidase B (MAO-B) inhibitor with a Ki of 875 nM. MAO-B-IN-47 shows an IC50 >100 μM for SH-SY5Y cells. MAO-B-IN-47 shows neuroprotective effect in 6-OHDA-treated SH-SY5Y cells. MAO-B-IN-47 can be used for the research of neurological disease, such as Parkinson’s disease (PD). | |||||||||||||||||||||
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